It is crunch time in Europe’s premier competition and our Champions League handicap betting tips preview some of the biggest clashes from this week's fixtures.
Arsenal trail Porto on aggregate, and the Gunners need a big home performance to bounce back into Champions League contention. Elsewhere, Barcelona and Borussia Dortmund are all square in their respective ties against Napoli and PSV Eindhoven.
Can these continental powerhouses produce big wins to progress? Find out in our Champions League handicap betting tips.
Champions League handicap betting tips – Our picks
Arsenal vs Porto – (Arsenal -1 handicap)
Porto edged Arsenal to a 1-0 win in the first leg of this round of 16 clash. Galeno’s 93rd-minute goal was the difference between the sides at the Estádio do Dragão.
This was the Gunners' only defeat since they returned to action from the winter break in mid-January. Arsenal have won eight of their last nine matches and scored 33 during this strong run of form.
Mikel Arteta’s side have been in particularly good form at home lately, winning four in a row at the Emirates and hitting the net 14 times. Such momentum will give the Gunners plenty of confidence to overturn a one-goal deficit from the first leg as they return to North London.
With an average possession of nearly 60% and 48 goals scored in 18 home matches in all competitions, Arsenal are likely to control proceedings at the Emirates. This could lead to a commanding victory for the hosts over their Portuguese opponents.
Barcelona vs Napoli – (Barcelona -1 handicap)
Barcelona were 15 minutes away from taking a 1-0 aggregate lead to the return leg at the Camp Nou. Robert Lewandowski gave Blaugrana the lead until Victor Osimhen hit back in the 75th minute.
To reach their first Champions League quarter-finals since 2019/20, Xavi’s Barca side must edge Serie A champions Napoli at home. That said, Barcelona will be confident of returning to Catalonia, having won three previous Champions League home matches this season, with nine goals scored.
Napoli may be lacking confidence when making the trip to Spain from Southern Italy. The Azzurri have struggled on their travels recently, losing five of their last eight on the road and failing to score in five of their last seven.
Xavi’s outfit will back themselves to take advantage in front of passionate home support, and the Catalans could secure passage to the Champions League's final eight.
Borussia Dortmund vs PSV Eindhoven – (Borussia Dortmund -1 handicap)
Borussia Dortmund made a near-perfect start during the first leg in Eindhoven when Donyell Malen fired BvB into the lead after 24 minutes. The Bundesliga side were largely in control with 14 shots and 55% possession, but Luuk de Jong gave PSV Eindhoven a fighting chance with a second-half penalty.
PSV face a sterner test in the second leg as they head across the Dutch-German border to Dortmund. BvB are undefeated in 13 of their 16 home matches in all competitions this season.
Edin Terzic’s side also held their own in the Champions League group stages against some of Europe’s best, drawing with AC Milan (0-0) and PSG (1-1) and beating Newcastle (2-0).
Dortmund have also been amongst the goals at home during this campaign and have struck two or more in three consecutive home matches. PSV have also shown some defensive feebleness lately, conceding at least once in five of their last six on the road.
The Signal Iduna Park will be fully behind BvB for this encounter and the visiting Rood-witten could be in for a long evening as they make the short trip into the Rhineland.
