Fresh from the high of a 9-3 aggregate win over PSV, Mikel Arteta's side welcome Chelsea to the Emirates.
Read on for the latest Arsenal first goalscorer odds and our picks, in what looks to be an intriguing London derby.
Arsenal first goalscorer odds: our picks
Leandro Trossard – 13/2
The bookmakers' favourite to open the scoring in this clash, for either side, is Leandro Trossard.
Trossard opened the scoring last season against the Blues in Arsenal's 5-0 rout of their London rivals.
The diminutive Belgian boasts two goals in his last three appearances against Chelsea, and is likely Arsenal's most reliable player in front of goal, should a chance fall his way.
Ethan Nwaneri – 15/2
Next up is Ethan Nwaneri, who, despite his tender years, has scored the most goals in all competitions of those available to Arteta for selection.
Nwaneri was quiet last time out against Manchester United, but we think the 17-year-old attacker will be back to his very best against the Blues, having been completely rested against PSV midweek.
Gabriel Martinelli – 15/2
Gabriel Martinelli also features among our picks. The Brazilian speedster has recovered from injury in the last week, making a pair of cameos against PSV and Manchester United.
Martinelli's return is all the more important given the absences of Bukayo Saka, Gabriel Jesus and Kai Havertz.
The 23-year-old could be a big part of the solution to the Gunners' goalscoring woes, and Arteta may look to get Martinelli closer to goal to make that happen.
Declan Rice – 15/1
There has been much debate on how best to use Declan Rice in this Arsenal side. But the truth is the England midfielder is a powerhouse who can perform just about anywhere.
Rice may be a superb defensive presence in front of the back four, but he has grown into a superb attacking presence too. The former West Ham man has netted two in his last two.
The first was a superb strike from the edge of the box to equalise against Manchester United, and the second came on Wednesday night against PSV, where Rice timed his run to perfection to meet Raheem Sterling's cross.
Looking for more on this game? Check out our Arsenal vs Chelsea predictions for more!
