It’s derby day in Seville on Sunday. Our Real Betis vs Sevilla prediction and La Liga betting tips consider whether the hosts can finally get one over on their local rivals, after a poor run of derby results.
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Real Betis vs Sevilla prediction: Isco to shine in feisty game
Key stats
- Our Real Betis vs Sevilla betting tips take into account that the last four meetings at the Benito Villamarin have served up four red cards in total.
- Betis are on their best run of the season, with five straight victories in La Liga.
- The visitors are yet to win away to current top-half opponents this term, losing three and drawing three.
Correct score prediction: Real Betis 2-1 Sevilla
Despite the clear superiority of Betis overall in the last couple of years, Sevilla have tended to rise to the occasion on derby day, which casts some doubt as to the likely outcome here.
Betis have been playing some really good football though, with January additions Antony and Cucho Hernandez boosting their attacking threat, and they look capable of edging this.
Pre-game odds and win probability: Hosts the clear favourites
- HOME: 10/11 (1.91) – 52.4%
- DRAW: 5/2 (3.50) – 28.6%
- AWAY: 3/1 (4.00) – 25.0%
*odds from Ladbrokes, subject to change
The hosts are the favourites according to the Real Betis vs Sevilla odds, with an implied probability of 52.4% that they win this match.
They head into it following a brilliant 3-2 comeback win at Leganes, with Isco’s goal sparking their second-half revival.
As for Sevilla, they were beaten 1-0 at home by Athletic Club last time out, ending a four-game unbeaten run.
For more from the upcoming matches in Europe, today’s free football tips look at some of the best picks.
Most recent H2Hs: Sevilla the dominant force on derby day
Our Real Betis vs Sevilla prediction suggests a 12-game unbeaten run in league derbies for the visitors could come to an end here.
Betis haven’t defeated their local rivals in La Liga since 2018, but they did win a Copa del Rey tie three years ago on this ground.
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Real Betis preview: Few problems for Pellegrini
The home team’s selection issues have mostly cleared up now, with midfielder Marc Roca the only player expected to be missing through injury here.
Predicted Lineup: Adrian (GK), Rodriguez, Bartra, Llorente, Sabaly, Altimira, Cardoso, J. Rodriguez, Isco, Antony & C. Hernandez
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D Osasuna 1 Real Betis 1 UEFA Conference League 08/05/25
D Fiorentina 2 Real Betis 2 Spain La Liga 04/05/25
W Espanyol 1 Real Betis 2 UEFA Conference League 01/05/25
W Fiorentina 1 Real Betis 2 Spain La Liga 24/04/25
W Valladolid 1 Real Betis 5
Sevilla preview: Double suspension blow for the visitors
Garcia Pimienta will be forced into a midfield reshuffle, given both Lucien Agoume and Djibril Sow are suspended. Tanguy Nianzou is out injured.
Predicted Lineup: Nyland (GK), Pedrosa, Salas, Bade, Carmona, Juanlu, Gudelj, Saul, Vargas, Romero & Lukebakio
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W Las Palmas 0 Sevilla 1 Spain La Liga 10/05/25
L Celta Vigo 3 Sevilla 2 Spain La Liga 04/05/25
D Leganes 2 Sevilla 2 Spain La Liga 24/04/25
L Osasuna 1 Sevilla 0 Spain La Liga 20/04/25
D CD Alaves 1 Sevilla 1
Player to watch – Isco
With better players around him now, and fully fit following his injury problems earlier in the campaign, Isco is playing at a very high level. He has six goals and two assists in his last six appearances.

Isco rolling back the years
The 32-year-old looks to be back to his best after some difficult years, including an ill-fated stint across the city at Sevilla. He averages 2.1 shots and 2.5 key passes per game in the Spanish top flight this term.