Sassuolo vs Lazio prediction, odds & betting tips – 14/09/2025
Sassuolo are winless against Lazio since 2021. (Photo by Imago)
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First Goalscorer - Mattia Zaccagni (Lazio)

Sassuolo have conceded the first goal of the game in five of their last six Serie A matches. Zaccagni's personal record against the Neroverdi points to him being a genuine hazard and potentially the first goalscorer in this matchup.

Still seeking their first victory since returning to Serie A, Sassuolo face a difficult test at home, as they host Roman powerhouse Lazio at the Mapei Stadium on Sunday, 14 September.

Keep close tabs on Serie A predictions after viewing our key Sassuolo vs Lazio tips below.

Sassuolo vs Lazio prediction: Biancocelesti to beat Neroverdi 

Key stats

  • Sassuolo have lost each of their last five league outings across Serie A and Serie B.
  • The Neroverdi are winless in back-to-back Serie A meetings against Lazio.
  • Lazio won nine of their last 12 Serie A away games as pre-match favourites (D1, L2).
  • The Biancocelesti are on a two-match winless streak away from home in the league.

Correct score prediction: Sassuolo 1-2 Lazio

As the only side yet to earn a point this season, Fabio Grosso’s Sassuolo face a daunting challenge against Lazio in their third Serie A fixture. After a 2-0 opening loss to reigning champions Napoli, they suffered a regrettable 3-2 defeat to underdogs Cremonese.

They now host a Lazio side riding high after a 4-0 victory over Hellas Verona, which helped Maurizio Sarri’s team rebound from a shocking opening day loss to minnows Como.

Sassuolo will be determined to avoid repeating their disastrous top-flight debut season in 2013/14, when they lost all three opening games. But with Lazio’s experience and clinical edge in attack, the visitors are expected to control the match and leave with all three points.

Pre-game odds and win probability: Away favourites

  • HOME: 5/2 (3.50) – 28.5%
  • DRAW: 12/5 (3.40) – 29.4%
  • AWAY: 21/20 (2.05) – 48.7%

*odds from Ladbrokes, subject to change

The hosts were put to the sword in their first home fixture against Napoli. The Neroverdi remain winless in three straight home league outings, and are priced at 5/2 (3.50) – a minority 28.5% win probability rate.

Lazio will be keen to record their first away win of the league season, as they aim to qualify for European competition this time, after missing out last season. They carry odds of 21/20 (2.05), suggesting a 48.7% chance of victory for the visitors.

One can find all our predictions for today’s games on our football betting tips page.

Most recent H2Hs: Lazio all the way

The two teams played out a 1-1 draw in their previous H2H at Stadio Olimpico last year, before which Lazio secured three 2-0 wins on the trot. Sassuolo’s last H2H win dates back to December 2021.

Italy Serie A 26/05/24

Lazio

Lazio

1
Sassuolo

Sassuolo

1

Italy Serie A 21/10/23

Sassuolo

Sassuolo

0
Lazio

Lazio

2

Italy Serie A 03/05/23

Lazio

Lazio

2
Sassuolo

Sassuolo

0

Italy Serie A 15/01/23

Sassuolo

Sassuolo

0
Lazio

Lazio

2

Italy Serie A 02/04/22

Lazio

Lazio

2
Sassuolo

Sassuolo

1

Sassuolo preview: Can the underdogs avoid a loss?

Laurs Skjellerup is sidelined for the Neroverdi due to fitness issues, while Kristian Thorstvedt is out with a head injury.

Predicted lineup: Muric (GK), Walukiewicz, Idzes, Muharemovic, Doig, Matic, Kone, Vranckx, Berardi, Pinamonti & Lauriente

Last five matches:

  • Cremonese 3-2 Sassuolo (Serie A)
  • Sassuolo 0-2 Napoli (Serie A)
  • Sassuolo 1-0 Catanzaro (Coppa Italia)
  • Brest 1-1 Sassuolo (Club Friendly)
  • Empoli 4-0 Sassuolo (Club Friendly)

Lazio preview: Favourites to grab maximum points

Sarri has a handful of absentees to deal with: Samuel Gigot, Nicolo Rovella, Manuel Lazzari, Patric and Matias Vecino.

Predicted lineup: Provedel (GK), Marusic, Gila, Romagnoli, Tavares, Guendouzi, Cataldi, Bashiu, Castellanos, Cancellieri & Zaccagni

Last five matches:

  • Lazio 0-2 Hellas Verona (Serie A)
  • Como 2-0 Lazio (Serie A)
  • Lazio 2-0 Atromitos (Club Friendly)
  • Burnley 0-1 Lazio (Club Friendly)
  • Galatasaray 2-2 Lazio (Club Friendly)

Player to watch: Mattia Zaccagni

Mattia Zaccagni
Zaccagni has a remarkable H2H record against Sassuolo. (Photo by Imago)

Lazio midfield talisman Zaccagni is a real threat for the Neroverdi. The 30-year-old scored in the previous H2H, a 1-1 draw, and has six goal contributions (G5, A1) in his last seven personal H2Hs against Sassuolo. He also netted Lazio’s second in the 4-0 win over Hellas Verona last matchday.

italy predictions

With a passport full of stories, Akhil has journeyed across Europe and beyond, immersed in the fabric of the beautiful game. From covering thrilling Milan derby nights at San Siro as a live match analyst to uncovering hidden talents in the Benelux region as a scout, his versatile and hybrid background allows him to deliver clear, engaging narratives that capture football's essence.