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Bayer Leverkusen - Roma
UEFA Europa League - BayArena
2nd Round

Bayer Leverkusen will look to keep their hopes of a historic treble alive when they take on Roma in the second leg of their Europa League semi-final on Thursday night.
The German side take a 2-0 lead into the second leg after an emphatic win in the Italian capital last week and it will take an almighty effort from Roma to turn the tie around. Ahead of kick-off, check out our Bayer Leverkusen vs Roma prediction.
Contents
Bayer Leverkusen vs Roma prediction: Party time in Germany
🔥Hot tip
Bayer Leverkusen to win
⚽ Correct score prediction
Bayer Leverkusen 2-1 Roma
💥 Both teams to score
Yes
Key stats
- Bayer Leverkusen are on a 48-game unbeaten run across all competitions.
- Roma have won just one of their last five matches in all competitions.
- La Lupa have won just one game outside of Italy in the Europa League this season.
Pre-game odds and win probability: More glory anticipated for Alonso's men
- HOME: 8/15 (1.53) – 65.2%
- DRAW: 16/5 (4.20) – 23.8%
- AWAY: 19/4 (5.75) – 17.4%
*odds from Ladbrokes, subject to change
The Bayer Leverkusen vs Roma odds tell us what we already know – Bayer Leverkusen are the overwhelming favourites for this tie and it would take a superhuman effort for Roma to win on the night, never mind win by a big enough margin to progress through to the Europa League final.
Leverkusen have been the best team in Europe's top five leagues this season and already have the Bundesliga title in the bag. They also have a German Cup final to look forward to, so a positive result on Thursday would put them in touching distance of a historic unbeaten treble – something no European club in history has ever achieved.
Roma have also had a decent season, albeit not at the same level as their opponents. Daniele de Rossi has come in and put the club back in the race for the top four in Italy, but the chances of them reaching a third consecutive European final seem next to zero, given the quality they are coming up against on Thursday night.
Extra free betting tips for Bayer Leverkusen vs Roma:
- Over 2.5 goals – 4/6 (1.67)
- Florian Wirtz to score anytime – 6/4 (2.5)
It is the second consecutive year that Roma and Bayer Leverkusen have met at this stage of the competition. Last season, Roma completed a ‘Mourinho masterclass' by winning 1-0 on aggregate over the two legs but this time, Leverkusen are out for revenge and they proved in the first leg that they aren't messing around.
UEFA Europa League 02/05/24
Roma
Bayer Leverkusen
UEFA Europa League 18/05/23
Bayer Leverkusen
Roma
UEFA Europa League 11/05/23
Roma
Bayer Leverkusen
UEFA Champions League 04/11/15
Roma
Bayer Leverkusen
UEFA Champions League 20/10/15
Bayer Leverkusen
Roma
Bayer Leverkusen preview: Edging closer to eternal glory
Given they already have the Bundesliga title secured, Xabi Alonso rested several players for the match against Frankfurt at the weekend. Despite winning 5-1, the Spaniard is certain to recall the likes of Jeremie Frimpong, Alex Grimaldo and Florian Wirtz who will be nice and fresh to give Roma and de Rossi plenty of headaches.
Predicted lineup: Kovar (GK), Tapsoba, Tah, Hincapie, Frimpong, Andrich, Xhaka, Grimaldo, Wirtz, Schick, Adli
Germany Bundesliga I 11/05/25
L
Borussia Dortmund
4
Bayer Leverkusen
2
Germany Bundesliga I 04/05/25
D
SC Freiburg
2
Bayer Leverkusen
2
Germany Bundesliga I 26/04/25
W
Augsburg
0
Bayer Leverkusen
2
Germany Bundesliga I 20/04/25
D
St Pauli
1
Bayer Leverkusen
1
Germany Bundesliga I 12/04/25
D
Union Berlin
0
Bayer Leverkusen
0
Roma preview: Looking to complete an almighty comeback
Daniele de Rossi will bring back Zeki Celik into the starting XI after the full-back missed the first leg. His replacement for that match, Rick Karsdorp, was booed off after making a critical error and is unlikely to feature again this season. There are doubts about Paulo Dybala's fitness but the Argentinian should make it.
Predicted lineup: Svilar (GK), Celik, Mancini, Smalling, Spinazzola, Cristante, Paredes, Pellegrini, Dybala, El Shaarawy, Lukaku
Italy Serie A 12/05/25
L
Atalanta
2
Roma
1
Italy Serie A 04/05/25
W
Fiorentina
0
Roma
1
Italy Serie A 27/04/25
W
Inter Milan
0
Roma
1
Italy Serie A 19/04/25
W
Verona
0
Roma
1
Italy Serie A 13/04/25
D
Lazio
1
Roma
1
Player to watch: Florian Wirtz

There have been standout players across the pitch for Bayer Leverkusen this season but the jewel in their crown is Florian Wirtz. The playmaker has been electric in all competitions and has contributed 15 goals and 15 assists.
More torment on the cards for Roma
Wirtz was at his brilliant best in the first leg and got things moving for Leverkusen with the opener in the first half. He created several more opportunities and will be looking forward to getting out there tonight.