All eyes will be on Estadio de la Cartuja as two of La Liga's top five teams go toe-to-toe with each other on Saturday, 6 December 2025.
View our free Real Betis vs Barcelona predictions below.
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Real Betis vs Barcelona predictions: Card fest
Key stats
- At least five cards were awarded in four of Real Betis’ last five matches.
- Barcelona have scored at least three goals in five consecutive La Liga games.
- Real Betis have no wins in their last nine skirmishes with Barcelona (D2, L7).
Correct score prediction: Real Betis 2-3 Barcelona
To be fair, Real Betis have enjoyed some fine form of late, stringing together a three-game winning streak and an eight-match unbeaten run across all competitions. However, they are up against La Liga's best team, as Barcelona are leading the standings after 15 games played.
Moreover, Barcelona have an excellent track record against Betis, especially at this stadium, where they won seven of their last eight trips.
On that note, we are confident that Barcelona will emerge victorious after 90 minutes.
Pre-game odds and win probability: Barcelona priced as favourites
- HOME: 14/5 (3.80) – 26.3%
- DRAW: 16/5 (4.20) – 23.8%
- AWAY: 4/5 (1.80) – 55.6%
*Odds from Ladbrokes, subject to change
Real Betis cruised to a comfortable 4-1 victory over fourth-tier minnows Torrent in the Copa del Rey earlier this week. That was their third consecutive win, and their sixth in eight games.
On the other hand, Barcelona are coming off a 3-1 victory over Atletico Madrid. They have won five consecutive La Liga games, scoring at least three goals in each of them.
As things stand, Real Betis are fifth in the Spanish top flight ahead of their clash with leaders Barcelona.
On that note, Barcelona are the expected winners at 4/5 (1.80). Teams with these odds generally have a 55.6% probability of winning.
Don’t forget to check out more of our best betting tips and predictions after you’ve dissected our Real Betis vs Barcelona predictions.
Also, keeping in mind that Barcelona led at half-time in five of their last six skirmishes with Real Betis, HT Barcelona to win has an appealing look at 6/5 (2.20). That one has a 45.5% chance of landing.
Most recent H2Hs: Business as usual for Barcelona?
Barcelona have no losses in their last nine meetings with Real Betis. The last time they lost at this stadium was in a January 2011 Copa del Rey clash.
Spain La Liga 05/04/25
Barcelona
Real Betis
Spain Copa del Rey 15/01/25
Barcelona
Real Betis
Spain La Liga 07/12/24
Real Betis
Barcelona
Spain La Liga 21/01/24
Real Betis
Barcelona
Spain La Liga 16/09/23
Barcelona
Real Betis
Real Betis preview: Few absentees
Real Betis will miss Isco Alarcon and Hector Bellerin for this game due to injury, while Giovani Lo Celso and Sofyan Amrabat remain doubtful.
The hosts went unbeaten last season in two league meetings against Barcelona, and with Antony back from suspension and ready for this game alongside Pablo Fornals and Abdessamad Ezzalzouli, Estadio Benito Villamarin could prove to be a tough nut to crack for the league leaders.
Predicted lineup: Valles (GK), Ruibal, Bartra, Natan, Gomez, Amrabat, Roca, Antony, Fornals, Ezzalzouli & Hernandez.
Last five matches
- Torrent 1-4 Real Betis
- Sevilla 0-2 Real Betis
- Real Betis 1-1 Utrecht
- Real Betis 1-1 Girona
- Valencia 1-1 Real Betis
Barcelona preview: Looking to extend their winning run
The treatment room for Barcelona has another new entry with Dani Olmo’s recent injury in the clash against Atletico Madrid on Tuesday night. Olmo joins Marc-Andre ter Stegen (back injury), Gavi (knee injury), and Fermin Lopez (calf injury) as the players ruled out of this important clash with Real Betis.
Raphinha was back to his best against Atleti and will feature alongside Lamine Yamal and Robert Lewandowski in the final third once again, while Pedri is expected to play in an advanced midfield role due to the absence of newly injured Olmo.
Predicted lineup: J. Garcia (GK), Kounde, Cubarsi, Martin, Balde, E. Garcia, De Jong, Yamal, Pedri, Lewandowski & Raphinha.
Last five matches
- Barcelona 3-1 Atletico Madrid
- Barcelona 3-1 Alaves
- Chelsea 3-0 Barcelona
- Barcelona 4-0 Athletic Bilbao
- Celta Vigo 2-4 Barcelona
Player to watch: Antony
Real Betis will be pleased to have Antony back in action after serving a one-game suspension. The former Manchester United player has six goal contributions in his last six appearances and will fancy his chances against Barcelona.