All eyes will be on Estadio de la Cartuja when Real Betis and Atletico Madrid battle for a place in the semifinal of the Copa del Rey on Thursday, 5 February 2026.
View our free Real Betis vs Atletico Madrid predictions below.
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Real Betis vs Atletico Madrid predictions: Visitors to draw first blood
Key stats
- Atletico Madrid opened the scoring in five of their last six matches and in 11 of the last 13 H2Hs.
- Real Betis conceded first in six of their last eight games.
- Both teams were on the scoresheet in six of Real Betis’ last eight matches across all competitions.
Correct score prediction: Real Betis 1-2 Atletico Madrid
To be fair, Atletico Madrid have not particularly enjoyed their best form of late, as they managed only one win in their last four games across all competitions.
However, Diego Simeone's troops have an excellent track record against Real Betis. They were victorious in the last two encounters between these teams and have lost only one of their last 13 clashes (W10, D2).
Considering their dominance in this fixture in recent years, we are leaning toward the visitors for the victory.
Pre-game odds and win probability: Betis up against it
- HOME: 11/5 (3.20) – 31.2%
- DRAW: 5/2 (3.50) – 28.6%
- AWAY: 11/10 (2.10) – 47.6%
*Odds from Ladbrokes, subject to change
Real Betis' comeback win against Valencia last weekend was their second consecutive victory and their fifth home win in a row across three different competitions.
Los Verdiblancos will now set their sights on advancing to the Copa del Rey's last four for the first time since the 2021/22 season, when they were champions.
On the other hand, Atletico Madrid played out a goalless draw with Levante last weekend. They are now without a win in two games and have won only one of their last four.
Despite their recent struggles, Atletico Madrid are the expected winners at 5/2 (3.50). Teams with these odds generally have a 28.6% probability of winning.
Don’t forget to check out more of our best betting tips and predictions after you’ve dissected our Real Betis vs Atletico Madrid predictions.
Also, keeping in mind that Atletico Madrid registered the first goal in 11 of their last 13 skirmishes with Real Betis, Atletico Madrid to score first has an appealing look at 3/4 (1.75). That one has a 57.1% chance of landing.
Most recent H2Hs: Atletico's dominance to continue?
It is safe to say that Real Betis do not particularly look forward to meeting Atletico Madrid, as they have managed only one win in the last 13 clashes between these teams, stretching back to December 2019.
In fact, Atletico have already beaten Betis at Estadio de la Cartuja this season.
Spain La Liga 27/10/25
Real Betis
Atletico Madrid
Spain La Liga 18/05/25
Atletico Madrid
Real Betis
Spain La Liga 27/10/24
Real Betis
Atletico Madrid
Spain La Liga 03/03/24
Atletico Madrid
Real Betis
Spain La Liga 20/08/23
Real Betis
Atletico Madrid
Real Betis preview: Long list of absentees
Boss Manuel Pellegrini continues to have a hard time on the injury front with his Real Betis side. For this game, up to five players are confirmed to be unavailable due to health issues, including Isco Alarcon, Cucho Hernandez, Junior Firpo, Rodrigo Riquelme, and Sofyan Amrabat.
Additionally, Giovani Lo Celso and Hector Bellerin are still struggling with fitness concerns, thereby making them doubtful for Thursday's game.
Predicted lineup: Adrian (GK), Ruibal, Diego Llorente, Bartra, Rodriguez, Altimira, Roca, Deossa, Antony, Ezzalzouli & Avila.
Last five matches
- Real Betis 2-1 Valencia
- Real Betis 2-1 Feyenoord
- Alaves 2-1 Real Betis
- PAOK 2-0 Real Betis
- Real Betis 2-0 Villarreal
Atletico Madrid preview: Looking to improve their fortunes
Head coach Simeone will be unable to call on the services of Alexander Sorloth, Rodrigo Riquelme, and Pablo Barrios due to injury, while veteran forward Antoine Griezmann’s fitness status remains questionable.
The visitors have acquired Ademola Lookman from Atalanta, but it is unclear if the Nigerian star will be ready for this crucial Copa del Rey fixture.
Predicted lineup: Musso (GK), Ruggeri, Hancko, Pubill, Molina, Cardoso, Llorente, Baena, Simeone, Almada & Alvarez.
Last five matches
- Levante 0-0 Atletico Madrid
- Atletico Madrid 1-2 Bodo/Glimt
- Atletico Madrid 3-0 Mallorca
- Galatasaray 1-1 Atletico Madrid
- Atletico Madrid 1-0 Alaves
Player to watch: Chimy Avila
Chimy Avila scored Real Betis' first goal in their 2-1 victory over Valencia last weekend. The former Osasuna forward, who has four goal contributions in as many Copa del Rey appearances, will fancy his chances against Atletico Madrid.