RB Leipzig vs Bayer Leverkusen prediction, odds & betting tips – 25/01/2025

RB Leipzig take on Bayer Leverkusen at the Red Bull Arena in a showpiece Bundesliga showdown on Saturday, 25 January. Read our German football predictions for the game below.

RB Leipzig vs Bayer Leverkusen prediction: Excitement likely in Leipzig

Key Stats

• Five goals rattled the net in each of the last three meetings between RB Leipzig and Bayer Leverkusen.
• Bayer Leverkusen have won each of their last eight matches in the Bundesliga.
• Bayer Leverkusen beat RB Leipzig 3-2 in two of the clubs’ last three encounters.
• Bayer Leverkusen picked up three yellow cards when the teams last met in August.

Correct score prediction: RB Leipzig 2-3 Bayer Leverkusen

RB Leipzig shocked champions Leverkusen in August (3-2), though they came out on the wrong side of two five-goal thrillers against Die Werkself before that and could be outgunned again here.

Pre-game odds and win probability: Bayer Leverkusen installed as favourites

• HOME: 13/5 (3.60) – 27.8%
• DRAW: 14/5 (3.80) – 26.3%
• AWAY: 10/11 (1.91) – 52.4%

*odds from Ladbrokes, subject to change

RB Leipzig threw away a three-goal lead to draw at bottom club Bochum in their last test and with their lax defending a factor, Die Roten Bullen have been priced as 13/5 underdogs ahead of an even stiffer challenge against the champions.

Bayer Leverkusen were narrow beaten by ten-man Atletico Madrid in the Champions League in midweek, though they have been on fire in the Bundesliga and have a 52.4% chance of rebounding with a win on Saturday. Check out more of our latest football predictions on our dedicated page.

Most recent H2Hs: Bayer Leverkusen have been on top

Bayer Leverkusen have won three of their last four meetings with RB Leipzig, though Die Roten Bullen came out on top when the sides last crossed paths in August.

Germany Bundesliga I 31/08/24

Bayer Leverkusen

2

RB Leipzig

3

Germany Bundesliga I 20/01/24

RB Leipzig

2

Bayer Leverkusen

3

Germany Bundesliga I 19/08/23

Bayer Leverkusen

3

RB Leipzig

2

Germany Bundesliga I 23/04/23

Bayer Leverkusen

2

RB Leipzig

0

Germany Bundesliga I 29/10/22

RB Leipzig

2

Bayer Leverkusen

0

RB Leipzig preview: Ronnow could miss out again

Timo Werner, Xaver Schlager, Andre Silva, Castello Lukeba, Benjamin Henrichs and Assan Ouedraogo are injured for RB Leipzig, however, crucially, both Lois Openda and Benjamin Sesko are available again following suspensions, adding considerably to the host's firepower.

Predicted lineup: Gulacsi (GK), Klostermann, Orban, Seiwald, Baku, Vermeeren, Kampl, Raum, Simon, Openda, Sesko

Germany Bundesliga I 10/05/25

D

Werder Bremen

0

RB Leipzig

0

Germany Bundesliga I 03/05/25

D

Bayern Munich

3

RB Leipzig

3

Germany Bundesliga I 26/04/25

L

Eintracht Frankfurt

4

RB Leipzig

0

Germany Bundesliga I 19/04/25

D

Holstein Kiel

1

RB Leipzig

1

Germany Bundesliga I 11/04/25

W

Wolfsburg

2

RB Leipzig

3

Bayer Leverkusen preview: Schlotterback still out

Martin Terrier, Odilon Kossounou, Jeanuel Belocian and Amine Adli are all likely to sit Saturday's game out through injury. Xabi Alonso used a 4-2-3-1 formation against Atletico Madrid in midweek, though he could revert to a three-at-the-back system on Saturday.

Predicted lineup: Hradecky (GK), Tah, Tapsoba, Hincapie, Frimpong, Palacios, Xhaka, Grimaldo, Wirtz, Tella, Schick

Germany Bundesliga I 11/05/25

L

Borussia Dortmund

4

Bayer Leverkusen

2

Germany Bundesliga I 04/05/25

D

SC Freiburg

2

Bayer Leverkusen

2

Germany Bundesliga I 26/04/25

W

Augsburg

0

Bayer Leverkusen

2

Germany Bundesliga I 20/04/25

D

St Pauli

1

Bayer Leverkusen

1

Germany Bundesliga I 12/04/25

D

Union Berlin

0

Bayer Leverkusen

0

Player to watch – Lois Openda

Belgian hitman Lois Openda is back from suspension and should return to the RB Leipzig XI at the weekend and the forward has an excellent recent record against Bayer Leverkusen.

Openda has punished Leverkusen before

Openda scored twice when RB Leipzig beat Leverkusen 3-2 in August and he has notched in each of his last three appearances against Die Werkself overall. The sharp-shooting 24-year-old could have a big part to play against the same opponents on Saturday.