The final Saturday night Bundesliga clash of 2025 is expected to be a real Christmas cracker as RB Leipzig welcome Bayer Leverkusen to the Red Bull Arena for a juicy top four encounter.
Can the hosts prevail in Saturday's clash, or will Leverkusen continue their top four push? Read our RB Leipzig vs Bayer Leverkusen prediction and preview to find out, but don't forget to also check out some of our other Bundesliga predictions.
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RB Leipzig vs Bayer Leverkusen prediction: Hosts defending perfect home record
Key Stats
- Leipzig are the only team in the Bundesliga to have a perfect home record, with six wins from six.
- Leipzig have scored 2+ goals in their last nine competitive home games.
- Just one of Leverkusen’s last six away matches saw both teams score.
- Leverkusen and Leipzig have scored a joint Bundesliga-high five goals each in the opening ten minutes this term.
Correct score prediction: RB Leipzig 2-2 Bayer Leverkusen
Bundesliga bosses have certainly given us a real Christmas treat in the final matchday of 2025. RB Leipzig and Bayer Leverkusen have produced 19 goals across their last four meetings, meaning we should be in for an entertaining encounter.
Leipzig have the advantage considering they boast a perfect home record with six wins form six. However, Leverkusen have picked up some notable away results this season, including a recent 2-0 win at Manchester City last month in the Champions League.
Pre-game odds and win probability: RB Leipzig backed to win
- HOME: 21/20 (2.05) – 48.80%
- DRAW: 11/4 (3.75) – 26.70%
- AWAY: 11/5 (3.20) – 31.30%
*Odds from Ladbrokes, subject to change
It's clear from these RB Leipzig vs Bayer Leverkusen odds that the bookies expect a win for the home team.
Nevertheless, if you liked our predictions for this game, remember to also check our betting tips for today.
Most recent H2Hs: Goals, goals, goals
Bayer Leverkusen have won three of their last five meetings with RB Leipzig, but none of the recent two. Their last head-to-head encounter took place last January and it ended in a 2-2 draw.
In total, the last four meetings have produced 19 goals, which is certainly a good sign for the neutrals who are looking forward to this goal festival.
Germany Bundesliga I 25/01/25
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Germany Bundesliga I 31/08/24
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Germany Bundesliga I 20/01/24
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Bayer Leverkusen
Germany Bundesliga I 19/08/23
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Germany Bundesliga I 23/04/23
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RB Leipzig preview: Frustration growing
RB Leipzig manager Ole Werner was not a happy man last weekend as his side missed the chance to close the gap on league leaders Bayern Munich following a 3-1 defeat at Union Berlin.
While Die Roten Bullen remain second in the Bundesliga, the gap between them and Bayern continues to grow. With that in mind, Leipzig cannot afford to drop more points as they look to mount some kind of title challenge.
On the personnel front, Yan Diomande and Amadou Haidara are competing at the Africa Cup of Nations. Ezechiel Banzuzi picked up a muscle injury, while Benjamin Henrichs is still dealing with his Achilles tendon problem. Antonio Nusa (ankle) and Assan Ouedraogo (knee) will also remain on the sidelines.
Predicted lineup: Gulacsi (GK), Nedeljkovic, Orban, Lukeba, Raum, Schlager, Seiwald, Baumgartner, Maksimovic, Harder, Gomis
Last five matches
- Union Berlin 3-1 RB Leipzig (Bundesliga)
- RB Leipzig 6-0 Eintracht Frankfurt (Bundesliga)
- RB Leipzig 3-1 1. FC Magdeburg (DFB Pokal)
- Borussia Monchengladbach 0-0 RB Leipzig (Bundesliga)
- RB Leipzig 2-0 SV Werder Bremen (Bundesliga)
Bayer Leverkusen preview: Visitors flying
Bayer Leverkusen are juggling a lot of plates this season, but it is fair to say they have enjoyed a strong campaign so far. Despite some recent bumps in the road, Die Werkself come into this game with great confidence thanks to their derby win over FC Koln.
Leverkusen will now be looking to strengthen their position in the top four ahead of the winter break, further boosting their hopes of Champions League qualification for next season.
When it comes to personnel, Christian Kofane, Ibrahim Maza and Edmond Tapsoba are all on international duty at AFCON. Jarell Quansah is suspended, while Exequiel Palacios remains on the injury list.
Predicted lineup: Flekken (GK), Andrich, Bade, Tape, Arthur, Fernandez, Tillman, Belocian, Hofmann, Terrier & Kofane
Last five matches
- Bayer Leverkusen 2-0 1. FC Köln (Bundesliga)
- Bayer Leverkusen 2-2 Newcastle United (Champions League) – Draw
- FC Augsburg 2-0 Bayer Leverkusen (Bundesliga)
- Borussia Dortmund 0-1 Bayer Leverkusen (DFB Pokal)
- Bayer Leverkusen 1-2 Borussia Dortmund (Bundesliga)
Player to watch: Christoph Baumgartner
If we had to pick one man to watch in this game, Christoph Baumgartner is the obvious choice. The player has been involved in 12 of Leipzig's 29 league goals this season, including six goals and six assists.

On top of that, Baumgartner also has five direct goal contributions in head-to-head games with Leverkusen, scoring three times.