Mainz 05 vs Hoffenheim prediction, odds & betting tips 21/11/2025
Mainz boss Bo Henriksen pictured during an interview - Photo by IMAGO / Middle East Images
🔥 Our Hot tip

Both teams to score

Hoffenheim's last four games have seen both teams score

Hoffenheim will be looking to secure a record-equalling fifth straight Bundesliga victory when they travel to the MEWA Arena for a clash with Mainz 05 this Friday night.

Can the visitors make history, or will Mainz end their woeful run of domestic results? Read our Mainz 05 vs Hoffenheim prediction and preview to find out, but don't forget to also check out some of our other Bundesliga predictions.

Mainz vs Hoffenheim prediction: Visitors to impress

Key Stats

  • Mainz are winless in their last two Friday night Bundesliga home matches.
  • Mainz have bagged the opening goal in just three Bundesliga games this season.
  • Hoffenheim are without a win in their last six Friday night games.

Correct score prediction: Mainz 1-2 Hoffenheim

The international break came at a good time for Mainz, who are looking to hit the restart button on their poor Bundesliga campaign.

For Hoffenheim, the World Cup qualifiers could not have arrived at a worse time. The team were in the midst of a four-match Bundesliga winning run, and they will be hoping to equal their club record on Friday with a fifth success.

Pre-game odds and win probability: Close game expected

  • HOME: 7/5 (2.40) – 41.70%
  • DRAW: 13/5 (3.60) – 27.80%
  • AWAY: 17/10 (2.70) – 37.00%

*Odds from Ladbrokes, subject to change

It's clear from these Mainz vs Hoffenheim odds that the bookies are anticipating a close encounter.

Nevertheless, if you liked our predictions for this game, remember to also check our betting tips for today.

Most recent H2Hs: Mainz have the edge

Mainz have won three of their last five head-to-head matches against Hoffenheim. They have also beaten their rivals in four straight meetings at the MEWA Arena.

Hoffenheim, however, picked up the win in their most recent meeting, running out 2-0 winners in April.

Germany Bundesliga I 12/04/25

TSG Hoffenheim

TSG Hoffenheim

2
Mainz

Mainz

0

Germany Bundesliga I 01/12/24

Mainz

Mainz

2
TSG Hoffenheim

TSG Hoffenheim

0

Germany Bundesliga I 13/04/24

Mainz

Mainz

4
TSG Hoffenheim

TSG Hoffenheim

1

Germany Bundesliga I 26/11/23

TSG Hoffenheim

TSG Hoffenheim

1
Mainz

Mainz

1

Germany Bundesliga I 04/03/23

Mainz

Mainz

1
TSG Hoffenheim

TSG Hoffenheim

0

Mainz preview: Domestic dip continues

Mainz are absolutely flying in the Europa Conference League, winning all three of their league phase matches. Trouble is, the same cannot be said about their Bundesliga campaign.

Bo Henriksen’s side have picked up just one point from their last six league matches, and they are without the injured duo of Anthony Caci and Maxim Dal.

Predicted lineup: Zentner (GK), Da Costa, Maloney, Kohr, Widmer, Sano, Amiri, Mwene, Nebel, Lee & Hollerbach

Last five matches

  • Eintracht Frankfurt 1-0 Mainz (Bundesliga)
  • Mainz 2-1 Fiorentina (UECL)
  • Mainz 1-1 Werder Bremen (Bundesliga)
  • Mainz 0-2 Stuttgart (DFB Pokal)
  • Stuttgart 2-1 Mainz (Bundesliga)

Hoffenheim preview: Big names in solid form

Hoffenheim are not just winning games, but they are also enjoying a tremendous goalscoring run having scored three times in each of their last four outings.

Goalkeeper Oliver Baumann is set to make his 500th Bundesliga appearance, while forward Andrej Kramaric will be looking to continue his fine start to the season.

Vladimir Coufal and Robin Hranac were both on the scoresheet for their country during the international break, and both are expected to feature on Friday.

Predicted lineup: Baumann (GK), Coufal, Hranac, Hajdari, Bernardo, Promel, Avdullahu, Burger, Kramaric, Lemperle, Toure

Last five matches

  • Hoffenheim 3-1 RB Leipzig (Bundesliga)
  • Wolfsburg 2-3 Hoffenheim (Bundesliga)
  • St Pauli 2-2 Hoffenheim (St Pauli win on pens – DFB Pokal)
  • Hoffenheim 3-1 Heidenheim (Bundesliga)
  • St Pauli 0-3 Hoffenheim (Bundesliga)

Player to watch: Andrej Kramaric

Andrej Kramaric pictured celebrating with Hoffenheim fans
Hoffenheim forward Andrej Kramaric scored a brace on his last outing against Mainz – Photo by IMAGO / Pressefoto Baumann

Hoffenheim forward Andrej Kramaric scored two goals when he last tested himself against Mainz in the Bundesliga.

The 34-year-old has made seven goal contributions in his last five outings for the club and he will be looking to continue that impressive form on Friday night.


Sports writer for Football Whispers and various other titles. After completing a sports journalism degree at Leeds Trinity University, he went on to work for William Hill, Planet Sport, Football365, League Express, Yorkshire Evening Post, Halifax Courier and others.