With Liverpool looking to win the EFL Cup for the 11th time, they will hope to advance into the fourth round of the competition, but they must first beat Southampton at Anfield on Tuesday.
The hosts have made a perfect start to the campaign in terms of results, and they find themselves top of the Premier League with 15 points from their first five games, while Southampton reside in 19th place in the Championship with just six points from six matches.
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Liverpool vs Southampton prediction: Ruthless hosts meet vulnerable Saints
Key stats
- Liverpool have scored in their last 39 Premier League games, and they have netted at least two goals in six of their past nine in the top flight.
- Southampton head to Anfield having conceded at least twice in four of their most recent five in all competitions.
- The hosts have kept just three clean sheets in 14 fixtures, and they have conceded seven goals in their six games this campaign.
Correct score prediction: Liverpool 3-1 Southampton
Liverpool may not be playing at their absolute best, but they have still been ruthless in the final third, and Southampton will find it difficult to get the better of the Merseysiders
Pre-game odds and win probability: Liverpool predicted to win by the bookmakers
- HOME: 2/13 (1.15) – 86.7%%
- DRAW: 8/1 (9) – 11.1%
- AWAY: 12/1 (13) – 7.7%
*odds from Ladbrokes, subject to change
Liverpool are the expected winner of this clash, with a probability of 86.7%, and the bookmakers do not believe that Southampton will pose enough of a challenge to have a realistic chance of advancing into the next round of the EFL Cup.
You can find all our predictions for today's games on our football betting tips page.
Most recent H2Hs: Liverpool dominance in front
A victory for Liverpool on Tuesday would be their fifth consecutive triumph against Southampton, and it would extend their unbeaten streak against the visitors to 10 games.
It should be noted that the Saints have scored in six of their past seven outings against the Reds, and two of their last three losses against Liverpool have been by one-goal margins.
England Premier League 08/03/25
Liverpool
Southampton
England EFL Cup 18/12/24
Southampton
Liverpool
England Premier League 24/11/24
Southampton
Liverpool
England FA Cup 28/02/24
Liverpool
Southampton
England Premier League 28/05/23
Southampton
Liverpool
Liverpool preview: Perfect start to the season
Liverpool have played five games in the Premier League and one match in the Champions League this season, with the club winning all six fixtures.
Head coach Arne Slot has indicated that a number of starters will not take part in Tuesday's game, including Mohamed Salah and Virgil van Dijk, though Alexander Isak is a candidate to start given he did not start against Everton on Saturday.
Predicted lineup: Mamardashvili (GK), Frimpong, Leoni, Gomez, Robertson, Nyoni, Endo, Ngumoha, Jones, Chiesa & Isak
Last five results:
- Liverpool 2-1 Everton
- Liverpool 3-2 Atletico Madrid
- Burnley 1-0 Liverpool
- Liverpool 1-0 Arsenal
- Newcastle United 2-3 Liverpool
Southampton preview: Will Still struggling at St Mary's
Will Still was appointed manager in May, and while he won his first two games in charge this season, jos side lost two, drew three and won just one of their subsequent six.
The Saints will want to use their clash against Liverpool as a springboard, and they will be boosted by the return of key midfielder Flynn Downes, who was left out of the squad that lost 3-1 against Hull City on Saturday due to illness.
Predicted lineup: McCarthy (GK) Edwards, Wood, Stephens, Roerslev, Fraser, Downes, Charles, Manning, Stewart & Archer
Last five results:
- Hull City 3-1 Southampton
- Southampton 0-0 Portsmouth
- Watford 2-2 Southampton
- Norwich City 0-3 Southampton
- Southampton 1-2 Stoke City
Player to watch: Rio Ngumoha
Rio Ngumoha has not been afforded a start yet for Liverpool this season, but after scoring the winning goal off the bench against Newcastle United earlier in August, fans are keen to see more of the 17-year-old.
The winger has featured from the bench in three of Liverpool's games in 2025-26, and he is seen as a genuine option in the first team, so expect him to make a big impact if he starts on Tuesday against Southampton.