A top-of-the-table clash unfolds at Stade Pierre-Mauroy when Lyon travel north to face LOSC Lille, as both teams return to domestic proceedings in the sixth round of Ligue 1 fixtures on Sunday, 28 September.
Keep close tabs on French Ligue 1 predictions after viewing our key Lille vs Lyon tips below.
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Key stats
- Lille have won only one of their last eight H2Hs across all competitions (D3, L4).
- Les Dogues have lost only one of their opening five Ligue 1 games (W3, D1)
- Lyon have lost seven of their last 12 away matches in the top-flight (W4, D1).
- Les Gones have scored first in each of their opening five league outings.
Correct score prediction: Lille 1-1 Lyon
A 3-0 defeat in the heated Derby du Nord against local rivals Lens confirmed Lille's first loss of the campaign. However, they bounced back against SK Brann in the UEFA Europa League, thanks to Olivier Giroud’s late winner. That triumph extended Lille’s unbeaten streak on home turf to seven straight games dating back to March.
Paulo Fonseca’s Lyon have been one of the early standout teams, and now stand the chance to register five wins from their first six matches for the first time since 2008/09. While back-to-back 1-0 wins have boosted confidence, there are concerns over an attack that has failed to score more than once in their last four outings.
With both sides managing the demands of European competition, this encounter is poised to mirror last season's tight affair at the Stade Pierre-Mauroy, and another closely-fought stalemate appears the most likely outcome.
Pre-game odds and win probability: Bookies back the Mastiffs
- HOME: 5/4 (2.25) – 44.4%
- DRAW: 5/2 (3.50) – 28.5%
- AWAY: 2/1 (3.00) – 33.3%
*odds from Ladbrokes, subject to change
Six of Lille’s last seven matches have seen over 2.5 goals scored, and bookmakers perhaps view this as an indication of a home victory. With 5/4 (2.25) odds, the Mastiffs are favourites with a 44.4% win probability rate.
Lyon, on the other hand, are also in impressive form, although they could considerably improve their offensive stride. The visitors are priced at 2/1 (3.00) odds, indicating a 33.3% chance of success.
Visit our football betting tips page for more free predictions.
Most recent H2Hs: Lyon with the upper hand
Lyon have won two of their last three H2Hs. However, their last visit to Pierre-Mauroy ended in a 1-1 draw. Lille are winless in seven of their last eight meetings with Lyon, with their only triumph across those fixtures coming in November 2023.
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Lille preview: Strong home form
Bruno Genesio misses Alexsandro, Thomas Meunier, Benjamin Andre, Romain Perraud and Ousmane Toure through injuries.
Predicted lineup: Ozer (GK), Mandi, Ngoy, Mbemba, Verdonk, Bentaleb, Bouaddi, Fernandez-Pardo, Haraldsson, Sahraoui & Giroud
Last five matches:
- Lille 2-1 SK Brann (UEFA Europa League)
- Lens 3-0 Lille (Ligue 1)
- Lille 2-1 Toulouse (Ligue 1)
- Lorient 1-7 Lille (Ligue 1)
- Lille 1-0 Monaco (Ligue 1)
Lyon preview: An important away victory?
Goalkeeper Remy Descamps is still suffering with a wrist injury, while Ernest Nuamah, Abner Vinicius and Orel Mangala are ruled out with injuries.
Predicted lineup: Greif (GK), Maitland-Niles, Mata, Niakhate, Tagliafico, Tessmann, Morton, Sulc, Tolisso, Fofana & Satriano
Last five matches:
- Utrecht 0-1 Lyon (UEFA Europa League)
- Lyon 1-0 Angers (Ligue 1)
- Rennes 3-1 Lyon (Ligue 1)
- Lyon 1-0 Marseille (Ligue 1)
- Lyon 3-0 Metz (Ligue 1)
Player to watch: Olivier Giroud

The veteran striker netted a late winner against SK Brann to hand Lille maximum points in their European opener this season. Giroud has two goals to his name this league term, with both strikes coming in the opening two matchdays against Brest and Monaco respectively. The 38-year-old is still performing at the highest levels and could well make the difference against Lyon.