Lille vs Lyon prediction, odds & betting tips – 28/09/2025
Lille and Lyon drew the last time they met at Stade Pierre-Mauroy. (Photo by Imago)
🔥 Our Hot tip

HT result: Lyon or draw

Lyon are the only team in Ligue 1 yet to concede before half-time this season.

A top-of-the-table clash unfolds at Stade Pierre-Mauroy when Lyon travel north to face LOSC Lille, as both teams return to domestic proceedings in the sixth round of Ligue 1 fixtures on Sunday, 28 September.

Keep close tabs on French Ligue 1 predictions after viewing our key Lille vs Lyon tips below.

Lille vs Lyon prediction: Spoils to be shared

Key stats

  • Lille have won only one of their last eight H2Hs across all competitions (D3, L4).
  • Les Dogues have lost only one of their opening five Ligue 1 games (W3, D1)
  • Lyon have lost seven of their last 12 away matches in the top-flight (W4, D1).
  • Les Gones have scored first in each of their opening five league outings.

Correct score prediction: Lille 1-1 Lyon

A 3-0 defeat in the heated Derby du Nord against local rivals Lens confirmed Lille's first loss of the campaign. However, they bounced back against SK Brann in the UEFA Europa League, thanks to Olivier Giroud’s late winner. That triumph extended Lille’s unbeaten streak on home turf to seven straight games dating back to March.

Paulo Fonseca’s Lyon have been one of the early standout teams, and now stand the chance to register five wins from their first six matches for the first time since 2008/09. While back-to-back 1-0 wins have boosted confidence, there are concerns over an attack that has failed to score more than once in their last four outings.

With both sides managing the demands of European competition, this encounter is poised to mirror last season's tight affair at the Stade Pierre-Mauroy, and another closely-fought stalemate appears the most likely outcome.

Pre-game odds and win probability: Bookies back the Mastiffs

  • HOME: 5/4 (2.25) – 44.4%
  • DRAW: 5/2 (3.50) – 28.5%
  • AWAY: 2/1 (3.00) – 33.3%

*odds from Ladbrokes, subject to change

Six of Lille’s last seven matches have seen over 2.5 goals scored, and bookmakers perhaps view this as an indication of a home victory. With 5/4 (2.25) odds, the Mastiffs are favourites with a 44.4% win probability rate.

Lyon, on the other hand, are also in impressive form, although they could considerably improve their offensive stride. The visitors are priced at 2/1 (3.00) odds, indicating a 33.3% chance of success.

Visit our football betting tips page for more free predictions.

Most recent H2Hs: Lyon with the upper hand

Lyon have won two of their last three H2Hs. However, their last visit to Pierre-Mauroy ended in a 1-1 draw. Lille are winless in seven of their last eight meetings with Lyon, with their only triumph across those fixtures coming in November 2023.

France Ligue 1 05/04/25

Lyon

Lyon

2
Lille

Lille

1

France Ligue 1 01/11/24

Lille

Lille

1
Lyon

Lyon

1

France Ligue 1 06/05/24

Lille

Lille

3
Lyon

Lyon

4

France Ligue 1 03/05/24

Lille

Lille

0
Lyon

Lyon

0

France Cup 07/02/24

Lyon

Lyon

2
Lille

Lille

1

Lille preview: Strong home form

Bruno Genesio misses Alexsandro, Thomas Meunier, Benjamin Andre, Romain Perraud and Ousmane Toure through injuries.

Predicted lineup: Ozer (GK), Mandi, Ngoy, Mbemba, Verdonk, Bentaleb, Bouaddi, Fernandez-Pardo, Haraldsson, Sahraoui & Giroud

Last five matches:

  • Lille 2-1 SK Brann (UEFA Europa League)
  • Lens 3-0 Lille (Ligue 1)
  • Lille 2-1 Toulouse (Ligue 1)
  • Lorient 1-7 Lille (Ligue 1)
  • Lille 1-0 Monaco (Ligue 1)

Lyon preview: An important away victory?

Goalkeeper Remy Descamps is still suffering with a wrist injury, while Ernest Nuamah, Abner Vinicius and Orel Mangala are ruled out with injuries.

Predicted lineup: Greif (GK), Maitland-Niles, Mata, Niakhate, Tagliafico, Tessmann, Morton, Sulc, Tolisso, Fofana & Satriano

Last five matches:

  • Utrecht 0-1 Lyon (UEFA Europa League)
  • Lyon 1-0 Angers (Ligue 1)
  • Rennes 3-1 Lyon (Ligue 1)
  • Lyon 1-0 Marseille (Ligue 1)
  • Lyon 3-0 Metz (Ligue 1)

Player to watch: Olivier Giroud

Olivier Giroud
Giroud has two goals to his name this league season. (Photo by Imago)

The veteran striker netted a late winner against SK Brann to hand Lille maximum points in their European opener this season. Giroud has two goals to his name this league term, with both strikes coming in the opening two matchdays against Brest and Monaco respectively. The 38-year-old is still performing at the highest levels and could well make the difference against Lyon.

france league 1 prediction

With a passport full of stories, Akhil has journeyed across Europe and beyond, immersed in the fabric of the beautiful game. From covering thrilling Milan derby nights at San Siro as a live match analyst to uncovering hidden talents in the Benelux region as a scout, his versatile and hybrid background allows him to deliver clear, engaging narratives that capture football's essence.