We're expecting Pep Guardiola to make big changes to his starting lineup for the trip to Leyton Orient in the FA Cup this weekend, but even that won't affect the odds as the Premier League side head into this one as the overwhelming favourite.
Contents
Leyton Orient vs Man City prediction: Away win and clean sheet?
Key Stats
- Leyton Orient have failed to score in three of their last five matches, including two of their last three home games.
- Manchester City have scored at least three goals in three of their last five fixtures.
- New Man City signing Omar Marmoush has scored 20 goals across all competitions this season for Frankfurt.
Correct score prediction: Leyton Orient 0-3 Man City
We're backing Manchester City to secure a comfortable 3-0 victory against their League One hosts this weekend, even if they do make wholesale changes to their starting lineup. The Citizens have scored at least three goals in three of their last five matches and they go up against an Orient side that have failed to score in three of their last five matches.
Pre-game odds and win probability: No chance of an upset?
- HOME: 25/1 (26.00) – 3.8%
- DRAW: 12/1 (13.00) – 7.7%
- AWAY: 1/10 (1.10) – 90.9%
*odds from Ladbrokes, subject to change
Man City are the expected winner of this game with a probability of 90.9% and it's hard to disagree with the bookmakers on this prediction.
You can find all our predictions for today's games on our football betting tips page.
Most recent H2Hs: Met twice before
These two teams have met twice before back in the 1962/63 season when Leyton Orient were a top-flight team but City picked up a home win and a draw on the road from their two league games.
Leyton Orient preview: Lost last home game
Leyton Orient welcomed one of their promotion rivals, Stockport County, to the Gaughan Group Stadium last weekend where a solitary goal proved enough to secure all three points.
That goal arrived in the 14th minute and went the way of Stockport who now sit six points clear of Leyton Orient in the League One table.
Predicted lineup: Keeley (GK), Cooper, Happe, Currie, Pratley, Brown, Galbraith, Abdulai, Markanday, Kelman & Donley
England League 1 10/05/25
D
Stockport
2
Leyton Orient
2
England League 1 03/05/25
W
Huddersfield
1
Leyton Orient
4
England League 1 26/04/25
W
Wycombe
0
Leyton Orient
1
England League 1 21/04/25
W
Cambridge Utd
1
Leyton Orient
2
England League 1 18/04/25
W
Barnsley
3
Leyton Orient
4
Man City preview: Thrashed by the Gunners
Manchester City would have been expecting a tough game away at Arsenal last time out but nobody expected the Citizens to end up so badly beaten.
The Gunners took an early lead but Erling Haaland equalised in the 55th minute to seemingly get Manchester City back into the game. However, it proved to be a false dawn for Guardiola's men as Arsenal scored four times without reply to win the match 5-1.
City were busy in the transfer market this month and we're expecting to see new signings Vitor Reis, Adbukodir Khusanov, Nico Gonzalez, Ujma Bah and Omar Marmoush in the FA Cup this weekend.
Predicted lineup: Ortega (GK), Lewis, Bah, Khusanov, Reis, Grealish, O'Reilly, McAtee, Gonzalez, Marmoush & Nunes
England Premier League 10/05/25
D
Southampton
0
Man City
0
England Premier League 02/05/25
W
Wolverhampton
0
Man City
1
England FA Cup 27/04/25
W
Nottm Forest
0
Man City
2
England Premier League 22/04/25
W
Aston Villa
1
Man City
2
England Premier League 19/04/25
W
Everton
0
Man City
2
Player to watch: Omar Marmoush
What a signing Omar Marmoush could prove to be for Manchester City going forward with the Egyptian international being likened by some to his fellow countryman Mo Salah.

Marmoush has featured in two games for Man City so far this season but is yet to open his account for the Citizens. The former Frankfurt man has scored 20 goals in all competitions this season and many expect him to become another goal-machine for Pep Guardiola once he has settled into the English game.
Marmoush will be looking to open his account for the Citizens
We're backing Marmoush to score his first Manchester City goal, or goals, against Leyton Orient this weekend, helping to guide the Citizens into the hat for the next round.