It is Premier League against Championship in the last 16 of the FA Cup as Fulham host Southampton at Craven Cottage at Sunday lunchtime. Both teams will be well up for this one with a quarter-final place at stake.
Fulham come into this clash off the back of a 1-0 defeat at home to West Ham United, while Southampton were 3-1 winners away at Sheffield Wednesday. Nonetheless, we are not expecting the Cottagers to have it all their own way against the Saints.
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Fulham vs Southampton prediction: Cottagers to claim close victory?
Key stats
- Fulham have won three of their last four games in all competitions.
- Southampton are unbeaten in nine matches across all competitions.
- Fulham are also unbeaten in the previous four H2Hs.
Correct score prediction: Fulham 2-1 Southampton
Fulham have home advantage on their side here, and with their overall Premier League quality, they should have too much for Southampton. However, the Saints are in great form themselves and should still cause some problems.
Pre-game odds and win probability: Fulham favourites with bookmakers
- HOME: 11/20 (1.55) – 64.5%
- DRAW: 17/5 (4.40) – 22.7%
- AWAY: 17/4 (5.25) – 19.0%
*odds from Ladbrokes, subject to change
As shown by the implied probabilities, Fulham are the favourites with bookmakers to win and progress into the next round. A draw in normal time can be backed at just under 23%, while a Southampton victory is rated at 19%.
Also, feel free to check out our dedicated Today’s betting tips page for more of our expert FA Cup predictions.
Most recent H2Hs: Fulham aiming for five unbeaten
As mentioned before, Fulham are unbeaten in the last four meetings. That includes three wins for the Cottagers, and they will be aiming to emerge victorious again against Southampton.
England Premier League 26/04/25
Southampton
Fulham
England Premier League 22/12/24
Fulham
Southampton
England Premier League 13/05/23
Southampton
Fulham
England Premier League 31/12/22
Fulham
Southampton
England Premier League 15/05/21
Southampton
Fulham
Fulham preview: Wilson still doubtful
Unfortumately for Fulham, Harry Wilson is still doubtful with injury. Kevin is also ruled out for the hosts.
Predicted lineup: Leno (GK); Tete, Diop, Bassey, Robinson; Iwobi, Berge; Bobb, Smith Rowe, Chukwueze & Muniz
Last five results:
- 04/03/26: Fulham 0-1 West Ham United (Premier League)
- 01/03/26: Fulham 2-1 Tottenham (Premier League)
- 22/02/26: Sunderland 1-3 Fulham (Premier League)
- 15/02/26: Stoke City 1-2 Fulham (FA Cup)
- 11/02/26: Manchester City 3-0 Fulham (Premier League)
Southampton preview: Robinson a doubt
Jay Robinson is a doubt for Southampton with injury. Mads Roerslev and Welington are both ruled out.
Predicted lineup: Peretz (GK); Bree, Harwood-Bellis, Stephens, Manning; Charles, Bragg; Matsuki, Azaz, Scienza & Larin
Last five results:
- 28/02/26: Sheffield Wednesday 1-3 Southampton (Championship)
- 24/02/26: Southampton 5-0 Queens Park Rangers (Championship)
- 21/02/26: Southampton 1-1 Charlton Athletic (Championship)
- 14/02/26: Southampton (p) 1-1 Leicester City (FA Cup)
- 10/02/26: Leicester City 3-4 Southampton (Championship)
Player to watch: Alex Iwobi

Alex Iwobi has been highly influential for Fulham in recent games, scoring twice and assisting once in his previous three appearances for the club. The Nigeria international is yet to make his mark in the FA Cup so far this season though, and will be aiming to put that right against Southampton should he be given a chance from the start.