Struggling Southampton play host to FA Cup semi-finalists Crystal Palace on Wednesday night and we're bringing you our predictions for the game.
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Southampton vs Crystal Palace prediction: The Eagles to win
Key Stats
- Crystal Palace have won four of their last five outings in the Premier League.
- Five of the last seven meetings between these two clubs across all competitions have produced over 2.5 goals.
- Eberechi Eze has had more shots than any other Crystal Palace player this season (83) and the midfielder is averaging 3.88 shots per 90 minutes in the Premier League.
Correct score prediction: Southampton 1-2 Crystal Palace
With Southampton scoring an average of 0.71 goals per home game this season and Crystal Palace averaging 1.46 goals on their travels, you can see why we've backed a correct score prediction of 2-1 in the visitor's favour.
Pre-game odds and win probability: Odds stacked against the Saints
- HOME: 23/5 (5.60) – 17.9%
- DRAW: 3/1 (4.00) – 25%
- AWAY: 20/29 (1.69) – 59.2%
*odds from Ladbrokes, subject to change
Crystal Palace are the expected winner of this game with a probability of 59.2% and it's hard to argue with the bookmakers on this prediction.
You can find all our predictions for today's games on our football betting tips page.
Most recent H2Hs: The Eagles dominate
Wednesday's guests have won four and lost one of their last five encounters with Southampton, running out 2-1 winners when the pair met in December for their reverse league meeting.
England Premier League 29/12/24
Crystal Palace
Southampton
England Premier League 15/04/23
Southampton
Crystal Palace
England FA Cup 07/01/23
Crystal Palace
Southampton
England Premier League 29/10/22
Crystal Palace
Southampton
England Premier League 30/04/22
Southampton
Crystal Palace
Southampton preview: Yet another defeat
Southampton once again failed to make the most of their home advantage when they played host to Wolves before the international break.
The visitors scored a goal in each half to establish a 2-0 lead and although Saint's substitute Ebere Onuachu pulled a goal back in the 75th minute, Wolves held firm to secure all three points.
William Smallbone, Jan Bednarek, James Bree, Taylor Harwood-Bellis, Ross Stewart and Juan Larios are all doubts for the midweek clash with Crystal Palace due to injury.
Predicted lineup: Ramsdale (GK), Manning, Walker-Peters, Sugawara, Stephens, Bella-Kotchap, Aribo, Ugochukwu, Sulemana, Dibling & Fernandes
England Premier League 10/05/25
D
Man City
0
Southampton
0
England Premier League 03/05/25
L
Leicester
2
Southampton
0
England Premier League 26/04/25
L
Fulham
2
Southampton
1
England Premier League 19/04/25
D
West Ham
1
Southampton
1
England Premier League 12/04/25
L
Aston Villa
3
Southampton
0
Crystal Palace preview: Eased past Fulham
The Eagles put in a commanding performance at Craven Cottage on Saturday and booked their place in the FA Cup semi-finals.
Eberechi Eze put in a man-of-the-match performance, scoring the first goal and setting up the second for Ismaila Sarr, while substitute Eddie Nketiah put the cherry on the top of the cake with the third and final goal late on. Jean-Philippe Mateta didn't score in the FA Cup win but has scored more non-penalty goals (7) than any other player in the Premier League in 2025.
Chadi Riad and Cheick Doucoure have been ruled out for the season, while Joel Ward and Will Hughes are both doubts for the Southampton game.
Predicted lineup: Henderson (GK), Guehi, Muñoz, Lacroix, Mitchell, Richards, Lerma, Eze, Wharton, Mateta & Sarr
England Premier League 11/05/25
W
Tottenham
0
Crystal Palace
2
England Premier League 05/05/25
D
Nottm Forest
1
Crystal Palace
1
England FA Cup 26/04/25
W
Aston Villa
0
Crystal Palace
3
England Premier League 23/04/25
D
Arsenal
2
Crystal Palace
2
England Premier League 19/04/25
D
Bournemouth
0
Crystal Palace
0
Player to watch: Eberechi Eze
Eberechi Eze is enjoying another fine season for Crystal Palace, providing the Eagles' creativity from the left-hand side, cutting in to cause mayhem in and around the opposition's penalty area.
Eze leads the way with six assists in the Premier League for Palace this season, as well as chipping in with a couple of goals.
Eze starred in the FA Cup quarter-final against Fulham
The Crystal Palace star has scored in each of his two outings for club and country, so you wouldn't bet against the England international scoring against Southampton on Wednesday night.