All eyes will be on Johan Cruijff Arena when Ajax host Inter Milan in the first round of the UEFA Champions League on Wednesday, 17 September 2025.
View our free Ajax vs Inter Milan predictions below.
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Ajax vs Inter Milan predictions: Goals expected
Key stats
- At least three goals were scored in six of Inter Milan's last seven matches.
- Ajax are unbeaten in their last 10 home games across all competitions.
- Five of Inter's last seven games produced goals at both ends.
Correct score prediction: Ajax 2-2 Inter Milan
In addition to being on a six-match unbeaten run across all competitions, Ajax have won each of their three home games this season by two-goal margins.
Inter, on the other hand, are coming off back-to-back losses, including a disappointing home defeat against Udinese in which they were the overwhelming favourites.
Despite being the underdogs, we are confident that Ajax will hold their own on Wednesday night.
Pre-game odds and win probability: Ajax are up against it
- HOME: 3/1 (4.00) – 25%
- DRAW: 11/4 (3.75) – 26.7%
- AWAY: 17/20 (1.85) – 54.1%
*Odds from Ladbrokes, subject to change
Ahead of this skirmish, Inter Milan are the expected winners at 17/20 (1.85). Teams with these odds generally have a 54.1% probability of winning.
Don’t forget to check out more of our best betting tips and predictions after you’ve dissected our Ajax vs Inter Milan predictions, as well as our BetMGM signup offer for this month.
Also, keeping in mind that five goals were scored on average in Inter Milan’s last three games, over 3.5 total goals has an appealing look at 17/10 (2.70). That one has a 37% chance of landing.
Most recent H2Hs: First encounter in 19 years
Ajax and Inter Milan will go toe-to-toe with each other for the first time since March 2006.
Interestingly, while Inter have a 3-1-1 win-draw-loss record in five previous encounters between these teams, their only defeat against Ajax came in the final of the UEFA Champions League in May 1972.
UEFA Champions League 08/03/22
Ajax
Inter Milan
UEFA Champions League 15/02/22
Inter Milan
Ajax
Ajax preview: A clean bill of health
Ajax have a fully fit squad ahead of their UEFA Champions League opener against Inter Milan.
Forwards Mika Godts, Steven Berghuis and Wout Weghorst have all started the season in fine form. With luck and youth on their side, the hosts will fancy their chances against a relatively old Nerazzurri side.
Predicted lineup: Jaros (GK), Gaaei, Itakura, Baas, Wijndal, Klaassen, Taylor, Regeer, Berghuis, Godts & Weghorst.
Last five matches
- Ajax 3-1 Zwolle
- Volendam 1-1 Ajax
- Ajax 2-0 Heracles
- GA Eagles 2-2 Ajax
- Ajax 2-0 Telstar
Inter Milan preview: Looking to get back on track
Despite finishing the thrilling 4-3 encounter with Juventus with cramps over the weekend, French center-forward Marcus Thuram is cleared and ready for Inter’s trip to Amsterdam on Wednesday and is in line to start alongside Lautaro Martinez in the final third.
Like their opponents, Inter have a clean bill of health for this game, making it easier for Cristian Chivu to select his strongest XI.
Predicted lineup: Sommer (GK), Akanji, Acerbi, Bastoni, Dumfries, Barella, Calhanoglu, Mkhitaryan, Augusto, Thuram & Martinez.
Last five matches
- Juventus 4-3 Inter Milan
- Inter Milan 1-2 Udinese
- Inter Milan 5-0 Torino
- Inter Milan 2-0 Olympiacos
- Monza 2-2 Inter Milan (3-5 AP)
Player to watch: Marcus Thuram
Marcus Thuram has been impressive so far, scoring three goals and providing an assist in three Serie A games this season. The French forward will be called upon to provide goals on Wednesday night.