AC Milan host Lecce at the San Siro on Tuesday in the Coppa Italia second round. The Rossoneri enter the game with confidence, having secured three wins in a row in the Italian Serie A and recently secured a 3-0 away victory against Udinese.
Meanwhile, the Salentians have had a poor start to the season and have failed to get a win in their first four games in the league. They will be looking to bounce back from a disappointing 2-1 home defeat to Cagliari.
Read our AC Milan vs Lecce predictions and preview to find out, but remember to also check our other Coppa Italia predictions.
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AC Milan vs Lecce prediction: The Lions should win easily
Key statistics
- AC Milan have gone into half-time with the lead in each of their last three meetings against Lecce.
- Over 3.5 have been played in three of their last five encounters.
- Their last two clashes have ended in a 3-0 scoreline in favour of AC Milan.
Correct score prediction: AC Milan 3-0 Lecce
AC Milan are currently in good form and they will look to extend their winning streak against Lecce. Due to their recent wins, we are predicting a 3-0 victory for the Rossoneri.
Milan has been dominant against Lecce in recent years, winning two of their last five games with a 3-0 scoreline and keeping a clean sheet in those matches. With a potent attack and a solid defence, Milan should have no trouble dispatching a Lecce side that has been struggling for form.
Pre-match odds and win probability: AC Milan given winnable odds
- Home: 3/10 (1.30) – 76.9%
- Draw: 17/4 (5.25) – 19.0%
- Away: 17/2 (9.50) – 10.5%
*Odds provided by Ladbrokes. Subject to change.*
Based on the odds given, Milan are heavy favourites with a 76.9% chance of winning at 1.30 odds. A draw is priced at 5.25, giving it a 19.0% likelihood, while Lecce are the underdogs with just a 10.5% chance at 9.50 odds, showing that the bookmakers favour the home side to win this game.
Most recent head-to-head: AC Milan with home advantage
Massimiliano Allegri’s side has dominated this encounter in recent meetings. In their last five head-to-head matches, the home team have won four, with one ending in a draw. Eusebio Di Francesco’s team have struggled to contain Milan and they have failed to claim a win against them. They will have to go the extra length to shock the host if they are to get a win.
Italy Serie A 29/08/25
Lecce
AC Milan
Italy Serie A 08/03/25
Lecce
AC Milan
Italy Serie A 27/09/24
AC Milan
Lecce
Italy Serie A 06/04/24
AC Milan
Lecce
Italy Serie A 11/11/23
Lecce
AC Milan
After reviewing our key AC Milan vs Lecce predictions, be sure to visit our website for the remaining football betting tips today.
AC Milan preview: Key players to miss cup game
Allegri’s side will be missing several key players for this match. Mike Maignan is sidelined with a thigh injury and is expected back in early October 2025. Ardon Jashari is also ruled out due to a muscle injury, with a similar return timeframe.
Rafael Leao is unavailable after picking up a calf injury and he too is targeting an early October return. These absences will require the manager to rely on squad depth to cover for the injuries in his team.
Predicted lineup: Terracciano (GK), Pavlovic, Gabbia, Estupinan, Tomori, Saelemaekers, Rabiot, Fofana, Modric, Pulisic & Gimenez
Last five fixtures
- 20.09.25 – Udinese 0 – 3 AC Milan
- 14.09.25 – AC Milan 1 – 0 Bologna
- 29.08.25 – Lecce 0 – 2 AC Milan
- 23.08.25 – AC Milan 1 – 2 Cremonese
- 17.08.25 – AC Milan 2 – 0 Bari
Lecce preview: Three players out of the clash
Francesco’s side will be without a few important players for this match. Balthazar Pierret is having gastrointestinal discomfort and could miss the game. Gaby Jean is sidelined with a cruciate ligament injury, while midfielder Filip Marchwinski is also out with a cruciate ligament injury.
Predicted lineup: Falcone (GK), Tiago Gabriel, Gaspar, Gallo, Kouassi, Ramadani, Alex Sala, Coulibaly, Pierotti, Sottil & Stulic
Last five fixtures
- 19.09.25 – Lecce 1 – 2 Cagliari
- 14.09.25 – Atalanta 4 – 1 Lecce
- 29.08.25 – Lecce 0 – 2 AC Milan
- 23.08.25 – Genoa 0 – 0 Lecce
- 15.08.25 – Lecce 2 – 0 Juve Stabia
Player to watch: Christian Pulisic

Christian Pulisic has been in superb form this season, most recently showing his quality with a brace in his last game against Udinese. The winger has scored three goals and provided two assists for his team this campaign. Pulisic will be eager to carry that momentum into this crucial cup game and play a decisive role for his side.