Tottenham will have one eye on the League Cup final ahead of Wednesday's clash with Southampton in the Premier League. Southampton, who narrowly missed out on the FA Cup final at the weekend, aren't quite safe from relegation just yet but a positive result at the Tottenham Hotspur Stadium would ease any fears considerably.

Read on for our full match preview and prediction for Tottenham vs Southampton in the Premier League.

Tottenham vs Southampton: Our Best Bets

All of our tips contain no bias and have been researched using the latest stats and figures available at the time of publication.

All odds are subject to change but the prices shown are correct on the date of publication. Please check with your bookmakers before placing any bets. 

Tottenham to Win

Tottenham have won four of their last seven encounters with Southampton, including a 5-2 victory in the pair's reverse league fixture back in September. Both of these teams have been struggling for wins of late but with the home advantage and having 2-days extra to prepare for this game, Spurs are expected to win.

BTTS

Both teams have scored in six of the last seven meetings between Tottenham and Southampton and we're expecting another goals-filled game on Wednesday. Four of Spur's last six outings have ended with both teams finding the back of the net, while three of Southampton's last four league games have also seen both teams score.

Over 2.5 Goals

Five of the last seven head-to-heads between these two clubs have produced over 2.5 goals, with 7-goals being scored when the two sides last met. At least three goals have also been scored in five of Tottenham's and five of Southampton's last six outings in all competitions.

All the stats and the latest odds for Tottenham vs Southampton

icon England Premier League
Tottenham Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
VS
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Southampton
April 21, 2021
No odds currently available - check again later

Tottenham vs Southampton

icon Head to Head

21/04/21
EPL
Tottenham Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham
2 - 1
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Southampton
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Southampton
20/09/20
EPL
Southampton Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Southampton
2 - 5
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Tottenham
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham
05/02/20
FA Cup
Tottenham Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham
3 - 2
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Southampton
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Southampton
25/01/20
FA Cup
Southampton Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Southampton
1 - 1
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Tottenham
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham
01/01/20
EPL
Southampton Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Southampton
1 - 0
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Tottenham
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham

Tottenham

Last 5

08/05/21
EPL
Leeds Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Leeds
3 - 1
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Tottenham
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham
02/05/21
EPL
Tottenham Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham
4 - 0
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Sheff Utd
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Sheff Utd
25/04/21
EFL Cup
Man City Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Man City
1 - 0
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Tottenham
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham
16/04/21
EPL
Everton Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Everton
2 - 2
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Tottenham
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham
11/04/21
EPL
Tottenham Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Tottenham
1 - 3
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Man Utd
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Man Utd

Southampton

Last 5

11/05/21
EPL
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Southampton
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Southampton
3 - 1
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Crystal Palace
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Crystal Palace
08/05/21
EPL
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Liverpool
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Liverpool
2 - 0
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Southampton
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Southampton
30/04/21
EPL
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Southampton
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Southampton
1 - 1
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Leicester
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Leicester
18/04/21
FA Cup
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Leicester
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Leicester
1 - 0
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Southampton
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Southampton
12/04/21
EPL
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) West Brom
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
West Brom
3 - 0
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21) Southampton
Tottenham vs Southampton Prediction, Odds and Betting Tips (21/4/21)
Southampton

Two teams looking to get back to winning ways lock horns on Wednesday

Tottenham were held to a 2-2 draw at Goodison Park last time out, throwing away the lead and having to rescue a share of the spoils in the end. With just one win in their last six matches across all competitions, Tottenham look like they could struggle to finish in the top four this season and really need a win on Wednesday to get themselves back on track. Clean sheets have been at a premium for Spurs of late and Southampton will provide another stern test for their backline on Wednesday night. The hosts will be without Davies once again and both Doherty and Kane will be assessed nearer to kick-off to see if they are fit to participate.

Southampton lost to Leicester in the FA Cup semi-final on Sunday and along with that result went another season without silverware. The Saints can now put their full concentration back on securing their Premier League status, which they are too far away from doing with 36pts on the board and seven games still to play. However, their form in the second have of the season has mostly been poor, culminating in a 3-0 defeat at West Brom in their last Premier League outing. Obafemi, Romeu and Smallbone will continue to miss out this week through injury.

Tottenham vs Southampton: Q&A

tottenham vs southampton prediction

  • Where can I watch this game in the UK? – Sky Sports Main Event / Sky Sports Premier League / Sky Sports Ultra HD
  • What was the score when these sides last met? – Southampton 2-5 Tottenham, 20/9/20
  • Where will this game be played? – Tottenham Hotspur Stadium (London)

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