Lazio and Sassuolo clash in Serie A this Sunday in what is the final game for the visitors as a top flight club following their relegation. Our Lazio vs Sassuolo prediction considers whether they can go out with a surprise win.

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Lazio vs Sassuolo prediction: Hosts to end season with convincing victory
The already-relegated Sassuolo won't have anything to play for in this match, while Lazio need at least a point to secure a spot in the Europa League, which is why we expect a convincing win for the hosts.
Key Stats
- Our Lazio vs Sassuolo betting tips take into account the home team’s five game winning streak in front of their own fans in Serie A.
- The side from the capital have won 56% of their home league fixtures this season overall.
- Sassuolo have let in 2.22 goals per away game on average, losing 72% of their road fixtures.
Pre-game odds and win probability: Lazio huge favourites to end with a win
- HOME: 1/3 (1.33) – 75.0%
- DRAW: 9/2 (5.50) – 18.2%
- AWAY: 7/1 (8.00) – 12.5%
*odds from Ladbrokes, subject to change
The hosts are the big favourites according to the Lazio vs Sassuolo odds with an implied probability of 75.0% that they win this game with European qualification already assured.
Lazio have been in great form of late and made it six unbeaten with a 1-1 draw away to champions Inter last time out thanks to a goal from Daichi Kamada.
There were contrasting emotions for Sassuolo who were relegated as a result of their 2-0 home defeat against Cagliari last weekend to the despair of everyone inside the Stadio Citta del Tricolore.
For more analysis, today’s free betting tips will guide you around the best picks from this week’s football action.
Last five H2Hs: Four straight wins for I Biancocelesti
Italy Serie A 21/10/23 Sassuolo Lazio Italy Serie A 03/05/23 Lazio Sassuolo Italy Serie A 15/01/23 Sassuolo Lazio Italy Serie A 02/04/22 Lazio Sassuolo Italy Serie A 12/12/21 Sassuolo Lazio
Our Lazio vs Sassuolo prediction is backed up by recent history with all of the last four meetings ending with victories for the Rome club. The last three have all ended with 2-0 scorelines in favour of Lazio.
Lazio Preview: Casale suspended for hosts
There are few significant issues on the injury front for Lazio, but they will be missing the suspended Nicolo Casale and could hand starts to a few fringe players.
Predicted Lineup: Provedel (GK), Gila, Patric, Romagnoli, Marusic, Vecino, Rovella, Pellegrini, Zaccagni, Kamada, Castellanos
Italy Serie A 13/04/25 D Roma 1 Lazio 1 UEFA Europa League 10/04/25 L Bodo/Glimt 2 Lazio 0 Italy Serie A 06/04/25 W Atalanta 0 Lazio 1 Italy Serie A 31/03/25 D Torino 1 Lazio 1 Italy Serie A 16/03/25 L Bologna 5 Lazio 0
Sassuolo Preview: Changes possible after relegation
The visitors could be somewhat experimental with nothing at stake now. They are without the suspended Matheus Henrique while Samu Castillejo and Domenico Berardi are injured.
Predicted Lineup: Consigli (GK), Ferrari, Kumbulla, Viti, Doig, Boloca, Thorstvedt, Obiang, Toljan, Lauriente Pinamonti
Italy Serie B 12/04/25 W Modena 1 Sassuolo 3 Italy Serie B 06/04/25 L Palermo 5 Sassuolo 3 Italy Serie B 29/03/25 W AC Reggiana 1 Sassuolo 5 Italy Serie B 15/03/25 W Cittadella 1 Sassuolo 2 Italy Serie B 09/03/25 D Bari 1 Sassuolo 1
Player to watch – Taty Castellanos
It has been a slightly frustrating first season in Italy for Taty Castellanos who has only managed four Serie A goals having scored four in one game for Girona last season against Real Madrid.

Better in the Second Half
Castellanos has frequently been used off the bench which to some extent explains why 75% of his goals have come after the break in the Italian top flight. However it’s a trend that has continued throughout his career with the Argentine scoring more Second than First Half goals in all four of his MLS campaigns while the same was true in La Liga last term.