For the first round of the UEFA Europa League game, Roma will take on LOSC Lille at the Stadio Olimpico on Thursday, with both teams looking for a strong start to their competition.
I Giallorossi come into this game in decent form, having won three Serie A matches in a row, with their recent win being a 2-0 home victory over Hellas Verona.
Lille, on the other hand, failed to build on their first Europa League win of the season against Brann and suffered a 1-0 league defeat against Lyon at home.
Read our Roma vs Lille predictions and preview to find out, but remember to also check our other UEFA Europa League predictions.
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Roma vs Lille prediction: Host to claim narrow victory
Key statistics
- Both teams have scored at least one goal in four of their last five games.
- Roma have won three of their last four Serie A games.
- The striker has found the net twice in his last two matches on the road.
Correct score prediction: Roma 2-1 Lille
Roma’s home advantage will play a big role in this encounter, which is why we are predicting a 2-1 victory for the Yellow-Reds. Heading into this game, the Mastiffs have shown they can cause an upset in games. Roma's home form has been consistent and their ability to grind out wins will be the deciding factor against the visitors. We believe Roma's home advantage and will be enough to secure a narrow victory.
Pre-match odds and win probability: Roma favoured at home
- Home: 8/11 (1.73) – 57.1%
- Draw: 14/5 (3.80) – 26.3%
- Away: 18/5 (4.60) – 21.7%
*Odds provided by Ladbrokes. Subject to change.*
Roma are favourites with a 57.1% chance of winning at 1.73 odds, reflecting their strong form at home. A draw is priced at 3.80 with a 26.3% chance, while Lille are given 4.60 odds with a 21.7% chance, suggesting the visitors face a tough challenge in Rome.
Most recent head-to-head: One win each for both teams
The head-to-head record between these two sides is very limited, as they have only met once before in a club friendly back in 2019. Roma won that game 3-2. Since it was just a friendly, it does not give a reliable indication of how they might perform in a competitive setting. However, the scoreline does suggest that both teams can create chances and find the net against each other.
After reviewing our key Roma vs Lille predictions, be sure to visit our website for the remaining football betting tips today.
Roma preview: Key players to miss game
Gian Piero Gasperini’s team will be without several players for this match. Edoardo Bove is sidelined due to heart problems with no clear return date. Paulo Dybala is also unavailable after suffering a leg injury and is expected to return in mid-October. Leon Bailey is doubtful with a muscle injury and may not be fit in time to feature.
Predicted lineup: Svilar (GK), Celik, N'Dicka, Wesley, Mancini, Angelino, Pellegrini, Kone, Cristante, Dovbyk & Soule
Last five fixtures
- 28.09.25 – AS Roma 2 – 0 Verona
- 24.09.25 – Nice 1 – 2 AS Roma
- 21.09.25 – Lazio 0 – 1 AS Roma
- 14.09.25 – AS Roma 0 – 1 Torino
- 30.08.25 – Pisa 0 – 1 AS Roma
Lille preview: Injury troubles in the squad
Bruno Genesio’s side will be missing several players for this match. Berke Ozer is sidelined with a thigh injury, while Romain Perraud is unavailable due to an ankle problem. Ugo Raghouber has a groin injury and Thomas Meunier is targeting an early October 2025 return from a similar issue.
Ousmane Toure faces a long spell out with a cruciate ligament injury and is not expected back until late April. Benjamin Andre is also ruled out as he recovers from a muscle injury.
Predicted lineup: Bodart (GK), Mandi, Verdonk, Ngoy, Tiago Santos, Bouaddi, Mukau, Fernandez-Pardo, Haraldsson, Correia & Giroud
Last five fixtures
- 28.09.25 – Lille 0 – 1 Lyon
- 25.09.25 – Lille 2 – 1 Brann
- 20.09.25 – Lens 3 – 0 Lille
- 14.09.25 – Lille 2 – 1 Toulouse
- 30.08.25 – Lorient 1 – 7 Lille
Player to watch: Mathias Fernandez-Pardo
One player to keep an eye on is Lille star Mathias Fernandez-Pardo. The young Belgian has impressed in recent games, scoring two goals and providing one assist in his last five appearances.
Beyond the stats, he has consistently troubled opponents, playing a key role in Lille's attacking build-up. With his pace, vision and technical skill, Fernandez-Pardo is likely to cause real problems for the Roma defence.