Real Madrid vs Juventus prediction, odds & betting tips 22/10/2025
🔥 Our Hot tip

Real Madrid to win to nil

Three of Real Madrid's last five wins have been to nil.

Real Madrid will take on Juventus in the UEFA Champions League on Wednesday, 22 October, in a clash between two European heavyweights.

The hosts are on maximum points after two matches played in this year's competition, and a win would put them in a commanding position with five games to play.

Juventus have more work to do, as the Old Lady have drawn both of their Champions League matches so far.

As part of this week's round of Champions League betting tips, check out our Real Madrid vs Juventus prediction below.

Real Madrid vs Juventus prediction: Los Blancos to turn the screw

Key Stats

  • Real Madrid have won nine of their last ten matches in all competitions.
  • Juventus have failed to win any of their last six matches in all competitions.
  • Kylian Mbappe has scored 15 goals in his last 11 appearances for club and country

Correct score prediction: Real Madrid 2-0 Juventus

Real Madrid are beginning to look like a formidable force this season, and this should be a match they use to show the rest of the competition that they mean business.

Pre-game odds and win probability: Real Madrid are odds-on favourites

  • HOME: 10/21 (1.48) – 67.7%
  • DRAW: 18/5 (4.60) – 21.7%
  • AWAY: 5/1 (6.00) – 16.7%

*odds from Ladbrokes, subject to change

The Real Madrid vs Juventus odds tell you everything you need to know about where these two clubs are at present. Ladbrokes have given the hosts a 67.7% chance of winning the match, while Juventus have been given just a 16.7% chance of securing all three points.

You can find all our predictions for today's games on our football betting tips page.

Most recent H2Hs: A repeat of the 2017 final

The clash on Wednesday night will be a repeat of the 2017 UCL final, which Real Madrid won 3-1. The two clubs have met since, including a quarter-final tie the following season, which Real Madrid also came out on top in. Can the Old Lady finally get one over Los Blancos this week?

FIFA Club World Cup 01/07/25

Real Madrid

Real Madrid

1
Juventus

Juventus

0

Elite Club Friendlies 03/08/23

Juventus

Juventus

3
Real Madrid

Real Madrid

1

Elite Club Friendlies 31/07/22

Real Madrid

Real Madrid

2
Juventus

Juventus

0

Elite Club Friendlies 04/08/18

Real Madrid

Real Madrid

3
Juventus

Juventus

1

UEFA Champions League 11/04/18

Real Madrid

Real Madrid

1
Juventus

Juventus

3

Real Madrid preview: Huge problems at the back

Real Madrid are dealing with a defensive injury crisis ahead of this one, and with El Clasico to come at the weekend, no risks will be taken. Antonio Rudiger and Dean Huijsen are both out, while Trent Alexander-Arnold and Ferland Mendy have only just returned to training. David Alaba will also need to be assessed after he was forced off at the weekend.

Predicted lineup: Courtois (GK), Valverde, Militao, Asencio, Carreras, Camavinga, Tchouameni, Bellingham, Guler, Vinicius, Mbappe

Last five results

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  • Chelsea 2-1 Liverpool
  • Chelsea 1-0 Benfica
  • Chelsea 1-3 Brighton
  • Lincoln 1-2 Chelsea

Juventus preview: Lacking confidence

After a bright start to the season, Juventus have slipped back into old habits and are now stuck in a rut of drawing too many football matches. They should throw caution to the wind on Wednesday, which could mean starts for Kenan Yildiz, Dusan Vlahovic, Jonathan David and Francisco Conceicao.

Predicted lineup: Di Gregorio (GK), Gatti, Rugani, Kelly, Kalulu, Locatelli, Cambiaso, Conceicao, Yildiz, Vlahovic, David

Last five results

  • Ajax 0-2 AZ Alkmaar
  • Sparta Rotterdam 3-3 Ajax
  • Marseille 4-0 Ajax
  • Ajax 2-1 NAC Breda
  • PSV 2-2 Ajax

Player to watch: Kylian Mbappe

Kylian Mbappe
Kylian Mbappe – Photo by ZUMA Press Wire

Kylian Mbappe is enjoying a superb start to the season, keeping pace with the likes of Erling Haaland and Harry Kane in terms of pure goalscoring. Given his natural qualities as a footballer, if he can keep scoring goals at his current rate, then the Ballon d'Or could be his to lose in 2026.


Andy is a freelance Sports Journalist with ten years of experience covering football in the United Kingdom and abroad for various publications including the Manchester Evening News, UtdReport and Football Whispers. Andy also has a keen interest in basketball, cricket, golf and tennis and has covered major sporting events such as the Masters in Augusta.