Real Betis travel to Portugal for the second leg of their Conference League tie. Our Vitoria Guimaraes vs Real Betis prediction and Conference League betting tips consider which team is most likely to progress after a 2-2 draw in the first leg.
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Vitoria Guimaraes vs Real Betis prediction: Isco to shine in another score draw
Key stats
- Our Vitoria Guimaraes vs Real Betis betting tips take into account that the visitors have only failed to score in one of their last 12 games.
- 10 of the last 14 Vitoria Guimaraes games have ended level.
- All of their last seven Conference League matches have seen both teams score.
Correct score prediction: Vitoria Guimaraes 2-2 Real Betis
Betis were firm favourites heading into this tie, but it’s Vitoria Guimaraes who have the better record in this competition this season, and they gave a good account of themselves in the first leg.
The Portuguese side remain unbeaten in the Conference League this term, but Betis are in really good form overall, and this promises to be another really competitive game, with several goals likely.
Pre-game odds and win probability: Betis the slight favourites
- HOME: 2/1 (3.00) – 33.3%
- DRAW: 21/10 (3.10) – 32.3%
- AWAY: 13/10 (2.30) – 43.5%
*odds from Ladbrokes, subject to change
The visitors are the favourites according to the Vitoria Guimaraes vs Real Betis odds, with an implied probability of 43.5% that they win this match.
They come into the game following a 1-0 win over Las Palmas in La Liga, with Diego Llorente grabbing the only goal.
As for Vitoria, they were 2-1 winners at Boavista in the Portuguese top flight at the weekend, with Tiago Silva scoring the winner from the spot.
For more from the upcoming matches in Europe, today’s free betting tips look at some of the best picks.
Most recent H2Hs: Visitors unbeaten in three meetings
Our Vitoria Guimaraes vs Real Betis prediction suggests this could end with a repeat of the 2-2 scoreline from the first leg, a game that saw the Spanish side pegged back twice having taken the lead through Isco and Cedric Bakambu.
The only previous meetings both ended in 1-0 Betis wins during the 2013/14 Europa League.
UEFA Conference League 06/03/25
Real Betis
Guimaraes
Vitoria Guimaraes preview: Few changes expected from last week
After a strong showing in Seville, we shouldn’t see too many changes from the home team. They are missing Bruno Gaspar and Gustavo Silva to injury.
Predicted Lineup: Varela (GK), Mendes, Villanueva, Borevkovic, Santos, Handel, T. Silva, N. Santos, J. Mendes, Embalo & Oliveira
Portugal Primeira Liga 11/05/25
L SC Farense 2 Guimaraes 1 Portugal Primeira Liga 03/05/25
W Nacional 1 Guimaraes 2 Portugal Primeira Liga 27/04/25
W Rio Ave 0 Guimaraes 3 Portugal Primeira Liga 19/04/25
L Benfica 3 Guimaraes 0 Portugal Primeira Liga 11/04/25
W Gil Vicente 0 Guimaraes 1
Real Betis preview: Midfield problems for Pellegrini
The visitors will have to cope without midfielders Johnny Cardoso and Marc Roca due to injuries. Giovani Lo Celso is rated doubtful.
Predicted Lineup: Vietes (GK), Perraud, Natan, Bartra, Sabaly, Altimira, Fornals, Isco, Abde Ez, Bakambu & Antony
Spain La Liga 11/05/25
D Osasuna 1 Real Betis 1 UEFA Conference League 08/05/25
D Fiorentina 2 Real Betis 2 Spain La Liga 04/05/25
W Espanyol 1 Real Betis 2 UEFA Conference League 01/05/25
W Fiorentina 1 Real Betis 2 Spain La Liga 24/04/25
W Valladolid 1 Real Betis 5
Player to watch – Isco
Isco is one of the most dangerous attacking players in La Liga right now, with four goals and an assist from his last four appearances in all competitions.
Isco back to his best?
We’ve witnessed an incredible transformation from Isco since he joined Betis in 2023, after several very challenging years. Injuries hampered him in the opening stage of this campaign, so he hasn’t featured much in the Conference League, but he’s averaging 2.5 key passes and 2.0 shots per game in the Spanish top flight.