Lyon will make the trip to Estadio de la Cartuja for their UEFA Europa League encounter with Real Betis on Thursday, 6 November 2025.
View our free Real Betis vs Lyon predictions below.
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Real Betis vs Lyon predictions: Both teams to find the net
Key stats
- Four of Lyon’s last six matches produced goals at both ends.
- Real Betis’ last five games went below the 4.5-card threshold.
- Lyon have no losses in their last four matches.
Correct score prediction: Real Betis 1-1 Lyon
While Lyon have had a perfect three wins from three in the UEFA Europa League, it is worth noting that the Ligue 1 giants are coming off back-to-back draws.
Real Betis, on the other hand, have drawn two of three games in this competition, and considering the only other encounter between these teams at this stadium ended in a stalemate, we believe the spoils will be shared after 90 minutes.
Pre-game odds and win probability: Real Betis are clear favourites
- HOME: 10/11 (1.91) – 52.4%
- DRAW: 13/5 (3.60) – 27.8%
- AWAY: 14/5 (3.80) – 26.3%
*Odds from Ladbrokes, subject to change
Real Betis have earned five points from a possible nine in the UEFA Europa League and are 16th in the league phase, while Lyon, who have three wins in as many matches, are third.
Ahead of this clash, Real Betis are the expected winners at 10/11 (1.91). Teams with these odds usually have a 52.4% probability of winning.
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Moreover, fewer than five cards were awarded in each of Real Betis' last five matches and in five of Lyon's last seven games. On that note, under 4.5 total cards has an appealing look at 1/1 (2.00). That one has a 50% chance of landing.
Most recent H2Hs: First meeting in 12 years
There have been two previous Real Betis vs Lyon clashes and both encounters took place during the 2013/14 UEFA Europa League.
As it stands, Betis have no wins (D1, L1) and no goals scored against Lyon
Real Betis preview: A few injury concerns
Real Betis remain without midfield maestro Isco Alarcon, who continues his recovery from a long-term leg injury, with Junior Firpo also unavailable due to a hamstring injury.
First-choice goalkeeper Pau Lopez has fitness issues and could be unavailable. Ricardo Rodriguez was withdrawn at half-time against Mallorca due to muscle discomfort, making him another doubt for this game along with Chimy Avila.
Predicted lineup: Valles (GK), Ruibal, Bartra, Gomez, Bellerin, Amrabat, Fornals, Lo Celso, Antony, Ezzalzouli & Hernandez.
Last five matches
- Real Betis 3-0 Mallorca
- Atletico Palma 1-7 Real Betis
- Real Betis 0-2 Atletico Madrid
- Genk 0-0 Real Betis
- Villarreal 2-2 Real Betis
Lyon preview: Looking to extend their unbeaten run
Ernest Nuamah and Orel Mangala both remain long-term absentees with cruciate ligament injuries, while Malick Fofana is ruled out due to an ankle sprain.
Martin Satriano is expected to spearhead the attack, while Corentin Tolisso gets tasked with creativity from the middle of the pack.
Predicted lineup: Greif (GK), Vinicius, Niakhate, Mata, Maitland-Niles, Carvalho, Morton, Moreira, Tolisso, Sulc & Satriano.
Last five matches
- Brest 0-0 Lyon
- Paris 3-3 Lyon
- Lyon 2-1 Strasbourg
- Lyon 2-1 Basel
- Nice 3-2 Lyon
Player to watch: Antony
Antony put in a man-of-the-match performance last weekend, scoring a brace and providing an assist in Real Betis' 3-0 victory over Mallorca. The former Manchester United midfielder will be called upon to provide goals on Thursday night.