The UEFA Champions League group stage continues with PSV Eindhoven welcoming Napoli to the Philips Stadion on Tuesday, October 21. Both clubs are competing fiercely in a tight group, making this third-round fixture critical for qualification hopes.
The home side head into this game following a 1-1 draw against Union SG in their last Champions League game and have gone on to win back-to-back games, with the recent win being a 2-1 victory over Go Ahead Eagles in the Eredivisie.
Meanwhile, the Italian champions have shown flashes of brilliance in recent outings, securing a vital 2-1 victory against Sporting CP in their last European fixture. However, they suffered a 1-0 defeat against Torino on their return from the international break.
Read our PSV vs Napoli predictions and preview to find out, but remember to also check our other UEFA Champions League predictions.
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PSV vs Napoli prediction: Away team to get a narrow win
Key statistics
- Napoli have won three of their last five games in all competitions.
- Napoli have won by a 2-1 scoreline in their last two games.
- Both teams have scored in their last four games.
Correct score prediction: PSV 1-2 Napoli
Both teams are in good form heading into this game, but the visitors are the better team, which is why we foresee a 2-1 win in favour of Napoli. The visitors possess superior quality in attack and will be eager to claim their second win in the competition.
Although PSV's ability to score in front of their home supporters cannot be overlooked. We anticipate another tight game with goals in it, but we expect Napoli to nick the win by a narrow margin.
Pre-match odds and win probability: Napoli slight favourites
- Home: 2/1 (3.00) – 33.3%
- Draw: 13/5 (3.60) – 27.8%
- Away: 6/5 (2.20) – 45.5%
*Odds provided by Ladbrokes. Subject to change.*
Napoli enter the match as slight favourites with a 45.5% chance of victory at 2.20 odds. PSV follow with a 33.3% chance at 3.00 odds, while the draw is priced at 3.60, giving it a 27.8% probability, indicating a competitive encounter that could be decided by fine margins.
Most recent head-to-head: European history limited but competitive
The competitive history between PSV and Napoli is not much. The two teams have not met in the UEFA Champions League group stage, with their last head-to-head match coming during the 2012/2013 UEFA Europa League competition.
In those two fixtures, PSV won one match 3-0 at home and the other one 3-1 away, which shows they can cause an upset in this tie.
After reviewing our key PSV vs Napoli predictions, be sure to visit our website for the remaining football betting tips today.
PSV preview: Few Injury concerns to key players
Peter Bosz’s side has a few injury concerns to contend with. Kilian Sildillia is nursing a thigh injury and remains doubtful for selection, while Alassane Plea is also a doubt due to a knee problem. Meanwhile, Ruben van Bommel is recovering from a knee injury and is expected to return in early November 2025.
Predicted lineup: Kovar (GK), Dest, Obispo, Gasiorowski, Salah-Eddine, Saibari, Schouten, Veerman, Man, Til & Perisic
Last five fixtures
- 18.10.25 – PSV 2 – 1 G.A. Eagles
- 04.10.25 – Zwolle 0 – 4 PSV
- 01.10.25 – Bayer Leverkusen 1 – 1 PSV
- 27.09.25 – Excelsior 1 – 2 PSV
- 21.09.25 – PSV 2 – 2 Ajax
Napoli preview: Multiple injury problems
Antonio Conte’s side has several injury issues to manage ahead of their Champions League clash against PSV. Nikita Contini is sidelined with a broken hand and is expected to return in late October, while Amir Rrahmani is also targeting a comeback around the same time as he recovers from a hamstring injury.
Stanislav Lobotka remains out with a thigh injury and is expected to return in November, whereas Romelu Lukaku is facing a longer spell on the sidelines due to a similar injury, with his comeback anticipated in November.
Predicted lineup: Meret (GK), Di Lorenzo, Beukema, Buongiorno, Spinazzola, Gilmour, Neres, Anguissa, De Bruyne, Lang & Hojlund
Last five fixtures
- 18.10.25 – Torino 1 – 0 Napoli
- 05.10.25 – Napoli 2 – 1 Genoa
- 01.10.25 – Napoli 2 – 1 Sporting CP
- 28.09.25 – AC Milan 2 – 1 Napoli
- 22.09.25 – Napoli 3 – 2 Pisa
Player to watch: Rasmus Hojlund
A key player to watch in this game is Napoli striker Rasmus Hojlund. The Danish forward has been a key player for the team this season, scoring five goals in all competitions for both club and country. As Napoli travel to face PSV, Hojlund will be keen to add to his goal tally and help his side push for another win.