Pisa SC will host Sassuolo at the Arena Garibaldi – Stadio Romeo Anconetani on Saturday, with the home side looking to bounce back from a heavy defeat in their last outing.
Pisa’s struggles deepened on Friday as a promising start against Inter Milan unravelled into a crushing 6-2 defeat, despite them having taken an early two-goal lead.
That loss stretched their Serie A winless run to 11 matches, and with just one league victory all season, they remain rooted to the bottom of the table. Even so, their situation is not yet beyond repair, as they sit only four points behind 17th-placed Lecce.
Any hopes of survival will likely depend on turning around their home form, where the Nerazzurri have been beaten in four of their last five league outings, drawing the other.
Sassuolo, who secured promotion alongside Pisa last season, have settled more comfortably into life back in the top flight. Their narrow 1-0 victory over Cremonese last time out halted a seven-match league winless streak and lifted them into mid-table.
The return of Domenico Berardi from a lengthy injury layoff added further encouragement for the Neroverdi, who will be looking to lean on their vice-captain to spark improvement on the road.
However, confidence away from home remains limited, with Sassuolo currently without a win in their last five away league matches, suggesting there are no guarantees of another positive result here.
Read our Pisa vs Sassuolo predictions and preview to find out, and remember to check our other Serie A predictions.
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Pisa vs Sassuolo prediction: Away team to get a narrow win
Key statistics
- Sassuolo have won two of their last five encounters with Pisa.
- Pisa have lost four of their last five home games in Serie A.
- BTTS have been scored in three of their last five meetings.
Correct score prediction: Pisa 1-2 Sassuolo
We expect the away team to edge out a victory in this competitive encounter. We predict a 2-1 win for Sassuolo based on their attacking quality and the positive momentum generated by their recent clean-sheet victory against Cremonese.
While Pisa showed flashes of brilliance by scoring two early goals against the league leaders last week, their defensive collapse in the second half suggests they remain vulnerable to dangerous attacks.
Sassuolo have a wealth of top-flight experience, and with the return of their key attackers, we believe they will find the back of the net twice. Pisa should be able to score at home, but the defensive discipline of the visitors should be enough to see them through.
Pre-match odds and win probability: Sassuolo are slight favourites
- Home: 15/8 (2.88) – 34.8%
- Draw: 21/10 (3.10) – 32.3%
- Away: 8/5 (2.60) – 38.5%
*Odds provided by Ladbrokes. Subject to change.*
The odds are slightly in favour of Sassuolo, with odds of 2.60 implying a 38.5% chance of an away win. Pisa are close behind at 2.88 (34.8%), while the draw is priced at 3.10, representing a 32.3% probability. Overall, bookmakers expect a tight contest with only a slight edge given to the visitors.
Most recent head-to-head: Tight record
Looking at their previous records, the recent meetings between these two clubs have been balanced, although the visitors have held a slight advantage lately. In their last five competitive meetings, Sassuolo have managed to win two times, while Pisa have recorded one victory, with two draws separating them.
The most recent clash in November 2025 ended in a thrilling 2-2 draw at the Mapei Stadium. Prior to that, Sassuolo secured a 1-0 win in March 2025, which avenged a 3-1 victory for Pisa in late 2024.
Italy Serie A 24/11/25
Sassuolo
Pisa
Italy Serie B 01/03/25
Sassuolo
Pisa
Italy Serie B 26/12/24
Pisa
Sassuolo
After reviewing our key Pisa vs Sassuolo predictions, be sure to visit our website for the remaining football betting tips today.
Pisa preview: Injury concerns affecting the team
Pisa have a lengthy list of absentees for this clash, with Adrian Semper, Daniel Denoon, Mateus Lusuardi, Raul Albiol, Calvin Stengs, Isak Vural, and Juan Cuadrado all sidelined through injury, limiting options across defence, midfield, and attack.
Predicted lineup: Scuffet (GK), Calabresi, Canestrelli, Coppola, Toure, Aebischer, Marin, Angori, Moreo, Tramoni & Hojholt
Last five fixtures
- 23.01.26 – Inter 6–2 Pisa
- 16.01.26 – Pisa 1–1 Atalanta
- 10.01.26 – Udinese 2–2 Pisa
- 06.01.26 – Pisa 0–3 Como
- 03.01.26 – Genoa 1–1 Pisa
Sassuolo preview: Injury list in the team
Sassuolo are missing Edoardo Pieragnolo, Fali Cande, and Daniel Boloca due to injury, slightly reducing Domenico Berardi’s squad depth as they look to improve their away form.
Predicted lineup: Muric (GK), Walukiewicz, Idzes, Muharemovic, Doig, Lipani, Matic, Kone, Fadera, Pinamonti & Lauriente
Last five fixtures
- 25.01.26 – Sassuolo 1–0 Cremonese
- 17.01.26 – Napoli 1–0 Sassuolo
- 10.01.26 – AS Roma 2–0 Sassuolo
- 06.01.26 – Sassuolo 0–3 Juventus
- 03.01.26 – Sassuolo 1–1 Parma
Player to watch: Andrea Pinamonti
Andrea Pinamonti is the player to watch for the away side as he looks to reclaim his spot as the focal point of the Neroverdi attack. The Italian striker has been in decent form this season with four goals and two assists to his name, proving to be a constant nuisance for the opposition.
The forward returned from injury against Cremonese and will be looking to help his team maintain an attacking threat in this game. With the home side currently struggling defensively, this match represents a perfect opportunity for the striker to add to his tally and help his team secure another vital victory.