Pisa are set to face Lazio on Thursday at the Arena Garibaldi in the Serie A as they look to find their way out of the relegation zone.
The newly promoted side have had a difficult start to their Serie A campaign, which has seen them sit at the bottom of the league table. They have failed to secure a win this season and ended up playing a 2-2 draw against AC Milan last weekend.
On the other hand, the Biancocelesti have been decent in their last five games, having recorded two wins, two draws and one loss. They returned to winning ways, defeating Juventus 1-0 the previous weekend following back-to-back draws.
Read our Pisa vs Lazio predictions and preview to find out, but remember to also check our other Serie A predictions.
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Pisa vs Lazio prediction: Visitors to nick win
Key statistics
- Lazio’s last away visit to Pisa ended in a win for them.
- The visitors won by a 1-0 scoreline on their last trip.
- Their last two meetings ended with under 1.5 goals scored.
Correct score prediction: Pisa 0-1 Lazio
Based on current form, Lazio have been the better side in the league, which is why we are tipping them to get a 1-0 victory in this game. Despite the Biancocelesti’s inconsistency this season, they have managed to build their momentum in their last five games. We expect them to take maximum points from the struggling Pisa side, who are yet to register a win this campaign.
Pre-match odds and win probability: Lazio favourites by bookmakers
- Home: 5/2 (3.50) – 28.6%
- Draw: 11/5 (3.20) – 31.3%
- Away: 23/20 (2.15) – 46.5%
*Odds provided by Ladbrokes. Subject to change.*
Lazio head into the clash as favourites with a 46.5% chance of victory at 2.15 odds, while Pisa are given a 28.6% chance to win at 3.50. The draw, priced at 3.20 (31.3%), remains a realistic possibility in what could be decided by a narrow margin.
Most recent head-to-head: One win each for both teams
There have not been many meetings between Pisa and Lazio, with the host just making it to the Serie A. However, based on their last two meetings, which were way back in the 90s, Lazio had just one win and the other ended in a draw. The Biancocelesti will be looking to get their first win over the Nerazzurri in this new century.
After reviewing our key Pisa vs Lazio predictions, be sure to visit our website for the remaining football betting tips today.
Pisa preview: Few players missing
Alberto Gilardino will face a difficult test against Lazio with several key players out injured for this clash. Mateus Lusuardi is doubtful due to physical discomfort, while Tomas Esteves and Calvin Stengs are also uncertain to feature because of muscle problems. Spanish star Raul Albiol remains sidelined with a broken hand and is expected to return in December.
Predicted lineup: Semper (GK), Canestrelli, Calabresi, Caracciolo, Toure, Tramoni, Aebischer, Akinsanmiro, Bonfanti, Meister & Nzola
Last five fixtures
- 24.10.25 – AC Milan 2 – 2 Pisa
- 18.10.25 – Pisa 0 – 0 Verona
- 05.10.25 – Bologna 4 – 0 Pisa
- 28.09.25 – Pisa 0 – 0 Fiorentina
- 25.09.25 – Torino 1 – 0 Pisa
Lazio preview: Multiple injuries for the visitors
Maurizio Sarri will have his work cut out while picking his team for this clash due to the injury issues in his team. Nuno Tavares remains sidelined with a muscle injury and is expected back in November, while both Samuel Gigot and Valentin Castellanos are doubtful due to similar issues. Fisayo Dele-Bashiru is recovering from a thigh problem and should return in November, the same timeline as Nicolo Rovella, Matteo Cancellieri and Toma Basic, who are nursing groin and muscle injuries, respectively.
Predicted lineup: Provedel (GK), Lazzari, Gila, Romagnoli, Marusic, Guendouzi, Cataldi, Vecino, Isaksen, Dia & Zaccagni
Last five fixtures
- 26.10.25 – Lazio 1 – 0 Juventus
- 19.10.25 – Atalanta 0 – 0 Lazio
- 04.10.25 – Lazio 3 – 3 Torino
- 29.09.25 – Genoa 0 – 3 Lazio
- 21.09.25 – Lazio 0 – 1 AS Roma
Player to watch: Mattia Zaccagni

Mattia Zaccagni has been a key player for Lazio this season despite not having enough numbers to back up his performance. However, he has scored one goal in his last three starts for his team. The attacker will be looking to use his experience in the game against Pisa, which can help his team seal a win.