A place in the knockout stages of the Copa Libertadores is at stake as Penarol and Rosario Central go toe-to-toe with each other on Tuesday. View our free Penarol vs Rosario Central predictions below.

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Penarol vs Rosario Central predictions: Hosts to advance to Round of 16
With both teams hoping to make it to the next stage of Copa Libertadores, we expect an exciting duel. That being said, Penarol have the advantage of playing at home and we can see that being the deciding factor.
Key stats
- This is a must-win for Rosario Central, while Penarol will advance to the next round if they don't lose this match.
- Penarol have won five matches in a row, with no losses in their last seven games.
- In contrast, Rosario Central managed just two wins in their last note matches across all competitions.
- Penarol conceded just once in their last five games.
Pre-game odds and win probability: Bookies favour the hosts
- Penarol: 1/1 (2.00) – 50%
- Draw: 21/10 (3.10) – 32.3%
- Rosario Central: 23/10 (3.30) – 30.3%
*Odds from Ladbrokes, subject to change
Penarol have two wins in as many fine games so far, scoring seven times without conceding. This is in contrast with Rosario Central, who are without a win in two road games.
Taking everything into account, Penarol are the expected winners at 1/1 (2.00). Teams with these odds usually have a 50% probability of winning.
Don’t forget to check out more of our best betting tips and predictions after you’ve dissected our Penarol vs Rosario Central predictions.
It's worth mentioning that just one goal was scored in the reverse fixture of this clash. Considering Penarol kept four clean sheets in their last five matches, and have not conceded at home in this tournament, under 2.5 total goals has an appealing look at 3/5 (1.60). That one has a 62.5% chance of landing.
Last five H2Hs: Can Rosario Central complete the sweep?
To be fair, Rosario Central emerged victorious by a lone goal when these teams clashed last month. However, they have struggled away from home, and are going up against a Penarol side that's on a five-match winning streak.
Copa Libertadores 04/04/24
Rosario Central
Penarol
Team news and form guide
Penarol: Eyeing their sixth consecutive victory
There are no new absentees for Penarol ahead of this encounter.
Predicted lineup: Rodriguez (GK), Castillo, Herrera, Coelho, Gianoli, Sosa, Ignacio, Cristoforo, Gonzalez, Babi & Neris.
Copa Libertadores 07/05/25
W
San Antonio Bulo Bulo
0
Penarol
3
Uruguay Apertura 03/05/25
W
Defensor Sporting
0
Penarol
1
Copa Libertadores 23/04/25
D
Olimpia Asuncion
0
Penarol
0
Uruguay Apertura 19/04/25
W
Montevideo Wanderers
1
Penarol
2
Uruguay Apertura 12/04/25
W
Miramar Misiones
2
Penarol
4
Rosario Central: Hoping to avoid the Copa Sudamericana
On the other hand, Rosario Central will have to do without a few players, including Agustin Sandez, Agustin Bravo, Abel Hernandez and Francis Mac Allister.
Predicted lineup: Werner (GK), Rodriguez, Gimenez, Komar, Coronel, Ibarra, Ortiz, Bogado, Gomez, Giaccone & Dupuy.
Argentina Liga Profesional 10/05/25
W
Estudiantes LP
0
Rosario Central
2
Argentina Liga Profesional 03/05/25
W
CA Independiente
0
Rosario Central
1
Argentina Liga Profesional 26/04/25
W
San Lorenzo
0
Rosario Central
1
Argentina Liga Profesional 20/04/25
W
Instituto AC Cordoba
0
Rosario Central
3
Argentina Liga Profesional 15/04/25
D
Platense
0
Rosario Central
0

Player to watch: Maximiliano Silvera
As it stands, Maximiliano Silvera is the joint top-scorer in the Copa Libertadores, alongside Atletico-MG's Paulinho. The former Santos forward has bagged five goals in as many group matches so far, he also found the net nine times in his last 11 games across all competitions.
Silvera scored in his last two appearances for Penarol, and he'll look to extend that scoring streak to three matches.