Olympiacos will welcome Real Madrid to Georgios Karaiskakis Stadium for their UEFA Champions League encounter on Wednesday, 26 November 2025.
View our free Olympiacos vs Real Madrid predictions below.
Contents
Olympiacos vs Real Madrid predictions: High-scoring affair
Key stats
- Four of Olympiacos’ last five matches went above the 2.5-goal threshold.
- At least five cards were awarded in four of Real Madrid's last five games.
- Olympiacos are currently on a six-match unbeaten run across all competitions.
Correct score prediction: Olympiacos 1-3 Real Madrid
To be fair, Olympiacos have no losses in their last six matches, while Real Madrid are on a three-game winless run.
However, there is a huge difference in quality between these squads, and while Real Madrid have three wins in four UEFA Champions League matches this season, Olympiacos are still hunting for their first win of the campaign.
In fact, Olympiacos have not won a UEFA Champions League game since October 2020. They are up against the most successful team in the history of this competition.
Taking everything into account, we are confident that Los Blancos will return to winning ways on Wednesday night.
Pre-game odds and win probability: Madrid priced as overwhelming favourites
- HOME: 5/1 (6.00) – 16.7%
- DRAW: 9/2 (5.50) – 18.2%
- AWAY: 4/9 (1.44) – 69.2%
*Odds from Ladbrokes, subject to change
Olympiacos cruised to a comfortable 3-0 victory over Atromitos last weekend, extending their unbeaten run across all competitions to six games (W5, D1).
However, while they are still in the hunt for their first win in the UEFA Champions League, it is important to note that the Greek Super League giants have no losses in their two home games.
On the other hand, Real Madrid are going through a rough patch, as they have no wins in three consecutive matches, failing to score in two of them. Los Blancos have been one of the best teams in this competition, however, earning nine points from a possible 12.
Ahead of this skirmish, Real Madrid are the expected winners at 4/9 (1.44). Teams with these odds usually have a 69.2% probability of winning.
Don’t forget to check out more of our best betting tips and predictions after you’ve dissected our Olympiacos vs Real Madrid predictions.
Also, keeping in mind that three of Olympiacos’ last four games produced goals at both ends, BTTS – Yes has an appealing look at 3/4 (1.75). That one has a 57.1% chance of landing.
Most recent H2Hs: First clash in 18 years
The most recent encounter between Olympiacos and Real Madrid took place in November 2007. Interestingly, Los Blancos have a 4-3-1 win-draw-loss record in eight meetings with Olympiacos stretching back to October 1997, and all their clashes took place in the UEFA Champions League.
Olympiacos preview: Clean bill of health
Olympiacos have a healthy squad ahead of this clash, which means head coach Jose Luis Mendilibar could resist the temptation of shuffling his pack from the three-goal victory against Atromitos last Saturday which consolidated their position on top of the Greece Super League.
While Thrylos have been great this season domestically, their form in the UEFA Champions League leaves nothing worthy of praise. However, against a Real Madrid side winless in their last three games and with the experienced Ayoub El Kaabi leading the line, Mendilibar’s men will fancy their chances of pulling off what would be their first win of the league phase.
Predicted lineup: Tzolakis (GK), Rodinei, Retsos, Pirola, Ortega, Garcia, Mouzakitis, Martins, Chiquinho, Podence & El Kaabi.
Last five matches
- Olympiacos 3-0 Atromitos
- Kifisia 1-3 Olympiacos
- Olympiacos 1-1 PSV
- Olympiacos 2-1 Aris
- Olympiacos 5-0 Volos
Real Madrid preview: Injury woes continue
Real Madrid are still battling injury problems with captain Dani Carvajal (knee), Antonio Rudiger (muscle), Aurelien Tchouameni (hamstring), Eder Militao (groin), Franco Mastantuono (groin), and David Alaba (muscle), with all of them expected to be out for this trip.
As regards the starting XI for this game, Xabi Alonso should make changes to the side that started the 2-2 draw against Elche last time out, with Vinicius Junior and Fede Valverde tipped to be in action from the first minute, while Trent Alexander-Arnold retains his place at right-back.
Predicted lineup: Courtois (GK), Alexander-Arnold, Asencio, Huijsen, Carreras, Valverde, Camavinga, Guler, Bellingham, Vinicius & Mbappe.
Last five matches
- Elche 2-2 Real Madrid
- Rayo Vallecano 0-0 Real Madrid
- Liverpool 1-0 Real Madrid
- Real Madrid 4-0 Valencia
- Real Madrid 2-1 Barcelona
Player to watch: Ayoub El Kaabi
Ayoub El Kaabi will fancy his chances against Real Madrid after scoring against their biggest rivals, Barcelona, in this competition last month. With seven goals and an assist in his last seven appearances for the club, the Moroccan forward will be called upon to provide goals on Wednesday night.