Newcastle vs PSV prediction, odds & betting tips 21/01/2026
Newcastle are bookies' favourites. Photo by IMAGO/ Pro Sports Images
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Newcastle to win to nil

Newcastle have won three of their last five Champions League matches without conceding a goal.

Newcastle will take on PSV in the UEFA Champions League on Wednesday, 21 January, in a huge match for both clubs.

A win for the hosts would give them a chance of qualifying for the Round of 16, while a win for the visitors would give them a great chance of qualifying for the playoffs.

As part of this week's round of UEFA Champions League betting tips, check out our Newcastle vs PSV prediction below.

Newcastle vs PSV prediction: The Blues to get what they need

Key Stats

  • Newcastle have won their last two Champions League home matches to nil
  • PSV have won just one of their three Champions League away matches this season.
  • Fewer than three goals have been scored in three of Newcastle's last five matches.

Correct score prediction: Newcastle 2-0 PSV

PSV are having an excellent run, which means this match will be relatively tricky for the Magpies. The St James' Park crowd could quite easily turn out to be the difference makers on Wednesday night.

Pre-game odds and win probability: Newcastle start as the favourites

  • HOME: 10/21 (1.48) – 67.7%
  • DRAW: 19/5 (5.50) 20.8%
  • AWAY: 19/4 (5.75) – 17.4%

*odds from Ladbrokes, subject to change

The Newcastle vs PSV odds indicate that the hosts will have it all their own way on Wednesday night. Ladbrokes have given Newcastle a 67.7% chance of winning the match, while PSV have been given just a 17.4% chance of victory.

You can find all our predictions for today's games on our football betting tips page.

Most recent H2Hs: A first competitive meeting in over 20 years

Wednesday will mark the first time that Newcastle and PSV have met on the football pitch since 2004. Back then, the two sides met in the quarter-finals of the UEFA Cup, with the Magpies winning 3-2 in the aggregate.

Newcastle preview: Injuries are piling up

Newcastle are enduring an injury crisis at present, which is all too familiar for Eddie Howe at this stage of the season. On Wednesday night, the Magpies will be without Tino Livramento, Fabian Schar, Jamaal Lascelles, Jacob Murphy, Dan Burn, William Osula and Emil Krafth.

Predicted lineup: Pope (GK), Miley, Thiaw, Botman, Hall, Tonali, Guimaraes, Joelinton, Elanga, Wissa, Barnes

Last five results

  • Wolves 0-0 Newcastle
  • Newcastle 0-2 Man City
  • Newcastle 2-2 Bournemouth
  • Newcastle 4-3 Leeds
  • Newcastle 2-0 Crystal Palace

PSV preview: An unchanged XI is expected

PSV are expected to field the same starting XI that came out on top at the weekend, as they are now on a stretch of six wins in a row in all competitions. On the injury front, the Dutch side are without Alassane Plea, Ruben van Bommel, Nick Olij, Ricardo Pepi, Sergino Dest and Myron Boadu.

Predicted lineup: Kovar (GK), Sildillia, Schouten, Gasiorowski, Junior, Wanner, Veerman, Perisic, Til, Driouech, Bajraktarevic

Last five results

  • Sittard 1-2 PSV
  • Den Bosch 1-4 PSV
  • PSV 5-1 Excelsior
  • Utrecht 1-2 PSV
  • PSV 3-0 GVVV

Player to watch: Yoane Wissa

Yoane Wissa
Yoane Wissa – Photo by IMAGO/ Pro Sports Images

Yoane Wissa is still waiting to properly get going in a Newcastle shirt, but that is understandable when you consider he missed the first four months of the season due to injury. The former Brentford man has just two goals to his name for his new club so far, but a goal or two tonight would go a long way to making him feel comfortable in black and white.

ucl predictions

Andy is a freelance Sports Journalist with ten years of experience covering football in the United Kingdom and abroad for various publications including the Manchester Evening News, UtdReport and Football Whispers. Andy also has a keen interest in basketball, cricket, golf and tennis and has covered major sporting events such as the Masters in Augusta.