Napoli vs Frankfurt prediction, odds & betting tips – 04/11/2025

Two teams that are separated by a place, but tied on three points, will go head-to-head in matchday four of the UEFA Champions League on Tuesday, November 4, 2025, at the Diego Armando Maradona Stadium.

Both sides will go out in search of redemption after heavy defeats in their respective gameweek three matches last time out. Napoli were trounced 6-2 by PSV Eindhoven, while Frankfurt suffered a 5-1 hiding at the hands of Liverpool.

Make the most of Today's Champions League predictions and betting tips.

Napoli vs Frankfurt predictions: The hosts have a slight edge

Key stats

• Napoli are unbeaten in their last three matches.
• The away side are unbeaten in their last three matches.
• Napoli have won their last two head-to-head meetings.

Correct score prediction: Napoli 2-1 Frankfurt

Napoli suffered a loss in their last Champions League outing, and the manner of the defeat was one the Neapolitans would not have expected. That said, the Italian side will be keen to get back to winning ways as soon as possible.

Frankfurt will also be looking to make amends for their heavy defeat on matchday two, but the home side will be too strong for the visitors, so we reckon Napoli will claim a narrow 2-1 victory.

Pre-game odds and win probability: Napoli are favoured by the bookmakers

• HOME: 3/5 (1.60) – 62.5%
• DRAW: 16/5 (4.20) – 23.8%
• AWAY: 4/1 (5) – 20%

**Odds from Ladbrokes, subject to change

Going by the calculations of the bookies, Napoli stands a better chance of claiming all three points, especially with odds of 3/5 (1.60), which translates to a 62.5% chance of that being the case.

Frankfurt, on the other hand, are underdogs with odds of 4/1 (5), which means a 20% probability that the Germans will emerge victorious on the day.

Most recent H2Hs: The hosts are gunning for a third consecutive win in this fixture

Napoli have had the better of Tuesday's opponents in their last two meetings, with the Italian side emerging victors by a 5-0 aggregate in their last couple of head-to-head encounters. Those matches were decided in February and March, with the Italians emerging victors on the two occasions.

Napoli Preview: Napoli will be looking to bounce back on Tuesday

Napoli have been enduring what can be described as a topsy-turvy run across all competitions. After losing back-to-back fixtures, Antonio Conte's men won two games on the bounce, but they were pegged back by the high-flying Como in the Serie A. Needing to make a move towards the top of the Champions League standings, the Italians will be desperate for a win on Tuesday.

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Predicted lineup: Milinkovic-Savic (GK), Spinazzola, Juan Jesus, Rrahmani, Di Lorenzo, Lobotka, Neres, McTominay, Anguissa, Politano & Hojlund

Last five matches

• Napoli 0-0 Como
• Lecce 0-1 Napoli
• Napoli 3-1 Inter
• PSV 6-2 Napoli
• Torino 1-0 Napoli

Frankfurt preview: Can the visitors claim their second win in four fixtures?

Frankfurt have also been inconsistent across different competitions. The Germans can only boast of a victory in regulation time in their last seven matches across all competitions. With their current form, they have to earn a positive result if they are to keep their hopes of making it to the next round in good standing.

Predicted lineup: Zetterer (GK), Kristensen, Koch, Theate, Doan, Larsson, Skhiri, Brown, Knauff, Burkardt, & Wahi

Last five matches

• Heidenheim 1-1 Frankfurt
• Frankfurt 1- 2 Dortmund
• Frankfurt 2-0 St Pauli
• Frankfurt 1-5 Liverpool
• Freiburg 2-2 Frankfurt

Player to watch: Jonathan Burkardt

Jonathan Burkardt has been impressive for Frankfyrt since the beginning of the season. His six strikes from eight fixtures is a testament to how instrumental he has been for the visiting side. With the Germans needing a positive result to get their Champions League campaign back on track, the 25-year-old German will be looking to help his team collect the much-needed three points on Tuesday.

Jonathan Burkardt in action for Frankfurt – Photo (Imago) Credit: HMB-Media

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