Genoa will look to extend their unbeaten opening-day streak to nine consecutive seasons when they welcome US Lecce to the Stadio Luigi Ferraris on Saturday, 23 August, to kick off the 2025/26 Serie A campaign.
Keep close tabs on Serie A predictions after viewing our key Genoa vs Lecce tips below.
Contents
Genoa vs Lecce prediction:
Key stats
- Genoa are winless in six of their last seven Serie A games.
- The Grifone scored a league-low 12 first-half goals last season.
- Lecce have won just two of their last 15 matches in the Italian top-flight
- The Salentini are winless in 10 straight trips to Luigi Ferraris, last winning away in 1998.
Correct score prediction: Genoa 3-1 Lecce
Genoa secured their Serie A status last season after a sluggish start, and under new manager Patrick Vieira, the Rossoblu appear to be building positive momentum. They capped the previous campaign with an impressive 3-1 win over Bologna and carried that form into an unbeaten preseason, followed by a confident 3-0 Coppa Italia victory in the season opener against Vicenza.
Their opponents, Lecce, narrowly avoided relegation by just three points and have now turned to Eusebio Di Francesco for a second spell in charge. The visitors face a tough historical precedent, having failed to win 11 of their last 12 meetings against Genoa. Furthermore, Lecce have lost 12 of their last 18 opening-day fixtures – a record that offers little encouragement ahead of their trip to a resurgent Genoa side. All elements point towards a controlled and convincing Genoa victory against Lecce’s well-documented struggles on the first day of the season.
Pre-game odds and win probability: Bookies favour the Ligurians
- HOME: 1/1 (2.00) – 50%
- DRAW: 9/4 (3.50) – 28.5%
- AWAY: 29/10 (3.90) – 25.6%
*odds from Ladbrokes, subject to change
Although Genoa’s last win in the first Serie A game of the season dates back to September 2020, when they beat Crotone 4-1, bookmakers strongly favour the hosts to triumph here. Odds of 1/1 (2.00) indicate a 50% chance of success for the Ligurian outfit.
Meanwhile, as expected, Lecce are the underdogs in this away fixture in Genoa, where they remain winless in top-flight history. Bookies have slapped 29/10 (3.90) odds on the visitors, implying a 25.6% win probability rate.
Don’t forget to check out more of our football betting tips page after analysing our Genoa vs Lecce predictions.
Most recent H2Hs: Can Lecce keep Genoa at bay?
Genoa are unbeaten in 16 of their 18 Serie A H2Hs (W10, D6), with Lecce’s two victories arriving at home at the Via del Mare in 2023 and 1990.
Italy Serie A 14/03/25
Genoa
Lecce
Italy Serie A 05/01/25
Lecce
Genoa
Italy Serie A 28/01/24
Genoa
Lecce
Italy Serie A 22/09/23
Lecce
Genoa
Italy Serie A 19/07/20
Genoa
Lecce
Genoa preview: A winning start?
Vieira is without the services of Caleb Ekuban and Sebastian Otoa, the only two confirmed absentees for the hosts in this league opener.
Predicted lineup: Leali, Norton-Cuffy, Ostigard, Vasquez, Martin, Frendrup, Masini, Carboni, Stanciu, Gronbaek & Colombo
Italy Serie A 11/05/25
D
Napoli
2
Genoa
2
Italy Serie A 05/05/25
L
AC Milan
2
Genoa
1
Italy Serie A 27/04/25
L
Como
1
Genoa
0
Italy Serie A 23/04/25
L
Lazio
2
Genoa
0
Italy Serie A 13/04/25
D
Verona
0
Genoa
0
Lecce preview: Can they upset the odds?
Gaby Jean and Filip Marchwinski are scheduled to sit this one out, while forward Santiago Pierotti is also expected to miss the clash.
Predicted lineup: Falcone (GK), Kouassi, Gabriel, Gaspar, Gallo, Coulibaly, Pierret, Helgason, Morente, Camarda & Sottil
Italy Serie A 11/05/25
D
Verona
1
Lecce
1
Italy Serie A 03/05/25
L
Napoli
1
Lecce
0
Italy Serie A 27/04/25
D
Atalanta
1
Lecce
1
Italy Serie A 19/04/25
L
Como
3
Lecce
0
Italy Serie A 12/04/25
L
Juventus
2
Lecce
1
Player to watch: Lorenzo Colombo
New Genoa signing Lorenzo Colombo has opened the scoring in eight of his 14 goal-scoring appearances in Serie A, including for Lecce three seasons ago. The former Salentini marksman, now on loan from AC Milan, could prove to make the difference here at the Luigi Ferraris in his top-flight debut for the Rossoblu.