Lyon are in a strong position to win their Europa League round-of-16 tie after a 3-1 win in Romania last week. Our Lyon vs FCSB prediction and Europa League betting tips consider whether they can finish the job back in France.
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Lyon vs FCSB prediction: Cherki to assist in comfortable home win
Key stats
- Our Lyon vs FCSB betting tips take into account that seven of the last nine Lyon matches have seen both teams score.
- Three of FCSB’s last four away games in this competition have served up over 2.5 goals.
- They’ve only failed to score in one of their last eight matches overall.
Correct score prediction: Lyon 3-1 FCSB
Lyon have already done the hard work in this tie by winning in Bucharest, and they should secure progress with relative ease on Thursday.
They’ve been in good form overall, with Rayan Cherki absolutely outstanding in recent matches, and he should be capable of leading Lyon to another comfortable win here.
Pre-game odds and win probability: Lyon the odds-on favourites
- HOME: 1/4 (1.25) – 80.0%
- DRAW: 19/4 (5.75) – 17.4%
- AWAY: 10/1 (11.00) – 9.1%
*odds from Ladbrokes, subject to change
The hosts are the favourites according to the Lyon vs FCSB odds, with an implied probability of 80.0% that they win this match.
They head into this game following a 2-0 win at Nice in Ligue 1, with Cherki and Ernest Nuamah grabbing late goals.
As for FCSB, they won 1-0 against CS Universitatea Craiova on Sunday in the Romanian top flight, with Adrian Sut grabbing the only goal.
For more from the upcoming games in Europe, today’s football betting tips look at some of the best picks.
Most recent H2Hs: FCSB winless in five meetings
Our Lyon vs FCSB prediction suggests the French side’s dominance of this fixture will continue on Thursday.
Lyon have won four of the five previous meetings in Europe, drawing the other. Malick Fofana scored twice in their 3-1 win in Romania last week.
UEFA Europa League 06/03/25

FCSB

Lyon
Lyon preview: Few selection issues for the hosts
There are no notable injuries right now for Lyon, with only light rotation likely from the first leg, despite their advantage.
Predicted Lineup: Perri (GK), Tagliafico, Niakhate, Mata, Maitland-Niles, Veretout, Matic, Nuamah, Tolisso, Cherki & Lacazette
France Ligue 1 09/03/25 W Nice 0 Lyon 2 UEFA Europa League 06/03/25 W FCSB 1 Lyon 3 France Ligue 1 02/03/25 W Brest 1 Lyon 2 France Ligue 1 23/02/25 L PSG 3 Lyon 2 France Ligue 1 16/02/25 W Montpellier 1 Lyon 4
FCSB preview: Injury problems for Charalambous
The visitors are missing Darius Olaru, Mihai Lixandru, Alexandru Pantea, William Baeten, Daniel Birligea and Octavian Popescu to injuries.
Predicted Lineup: Tarnovanu (GK), Radunovic, Popescu, Ngezana, Cretu, Sut, Alhassan, Cisotti, Edjouma, Miculescu & Tanase
Romania Liga I 09/03/25 W CS U Craiova 0 FCSB 1 UEFA Europa League 06/03/25 L Lyon 3 FCSB 1 Romania Liga I 02/03/25 D Rapid Bucuresti 0 FCSB 0 Romania Liga I 23/02/25 W Dinamo Bucharest 1 FCSB 2 UEFA Europa League 20/02/25 W PAOK Salonika 0 FCSB 2
Player to watch – Rayan Cherki
Cherki is on the very top of his game right now for Lyon. He has three goals and eight assists in his last seven appearances in all competitions.

Cherki shining in Europe
In eight Europa League appearances so far this term, Cherki has two goals and six assists. He’s averaging 3.8 key passes per game in the competition.