Just three days on from their tasty clash in the Bundesliga, Borussia Dortmund and Bayer Leverkusen are preparing to share the stage for the second time – on this occasion in the DFB Pokal.
Can the hosts prevail in Tuesday's match, or will Leverkusen avenge their league defeat and secure their spot in the quarter-finals of the cup? Read our Borussia Dortmund vs Bayer Leverkusen prediction and preview to find out, but don't forget to also check out some of our other football predictions.
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Borussia Dortmund vs Bayer Leverkusen prediction: Home form key
Key Stats
- Borussia Dortmund have not lost a competitive game at home since March.
- Bayer Leverkusen won the DFB Pokal in 2024.
- Borussia Dortmund won their last two meetings with Die Werkself.
- Bayer Leverkusen have scored 13 goals across their last five matches.
Correct score prediction: Borussia Dortmund 3-2 Bayer Leverkusen
Borussia Dortmund put on a solid performance in their 2-1 victory over Leverkusen on Saturday, and they will now be looking for a repeat of that result.
The Prussians have a tremendous record on home soil, and they will be full of confidence ahead of this upcoming cup clash. The same cannot be said about Leverkusen, who were not at the races when these two teams met at the weekend.
Pre-game odds and win probability: Bookies back Dortmund
- HOME: 83/100 (1.83) – 54.60%
- DRAW: 13/5 (3.60) – 27.80%
- AWAY: 12/5 (3.40) – 29.40%
*Odds from Ladbrokes, subject to change
It's clear from these Borussia Dortmund vs Bayer Leverkusen odds that the bookies expect a win for the home team.
Nevertheless, if you liked our predictions for this game, remember to also check our betting tips for today.
Most recent H2Hs: Dortmund have the edge
Borussia Dortmund have now won back-to-back games against recent German champions Bayer Leverkusen – a stat which will fill the hosts with confidence ahead of Tuesday's cup game.
Die Werkself boast just one win in seven against BVB, with their sole success in that time coming last January.
Germany Bundesliga I 29/11/25
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Germany Bundesliga I 11/05/25
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Germany Bundesliga I 10/01/25
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Germany Bundesliga I 21/04/24
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Germany Bundesliga I 03/12/23
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Borussia Dortmund preview: Momentum is building
Two straight wins, four games unbeaten – things are certainly looking up for Niko Kovac and his men, who are looking to be competitive on all fronts.
When it comes to injury news, forward Maximilian Beier is expected to miss out though a muscle injury. He will be joined on the sidelines by Niklas Sule, who has been out of action with a toe problem.
Predicted lineup: Kobel (GK), Anselmino, Anton, Schlotterbeck, Ryerson, Sabitzer, Nmecha, Svensson, Brandt, Adeyemi & Guirassy
Last five matches
- Leverkusen 1-2 Dortmund (Bundesliga)
- Dortmund 4-0 Villarreal (Champions League)
- Dortmund 3-3 Stuttgart (Bundesliga)
- Hamburger SV 1-1 Dortmund (Bundesliga)
- Man City 4-1 Dortmund (Champions League)
Bayer Leverkusen preview: Visitors plot revenge
Saturday's defeat to Dortmund ended Bayer Leverkusen's four-match winning run – a spell of games which included a Champions League victory over Manchester City away at the Etihad Stadium.
Leverkusen will be looking to avenge their defeat, but that could prove tricky with the amount of players on the sidelines.
Brazil’s Arthur, for instance, has been dealing with a back injury and he remains a doubt. Ezequiel Fernandez, Exequiel Palacios, Axel Tape and Lucas Vazquez are also out of action.
Predicted lineup: Flekken (GK), Andrich, Bade, Tapsoba, Hofmann, Maza, Garcia, Grimaldo, Tillman, Poku & Schick
Last five matches
- Leverkusen 1-2 Dortmund (Bundesliga)
- Man City 0-2 Leverkusen (Champions League)
- Wolfsburg 1-3 Leverkusen (Bundesliga)
- Leverkusen 6-0 Heidenheim (Bundesliga)
- Benfica 0-1 Leverkusen (Champions League)
Player to watch: Karim Adeyemi

Karim Adeyemi has been on fire since returning from the international break, with the German star rattling the net in three successive outings.
The 23-year-old forward scored the deciding goal against Leverkusen on Saturday, and he will be looking to have another big impact on Tuesday night.