All eyes will be on Riyadh Air Metropolitano as Atletico Madrid and Inter Milan lock horns in the league phase of the UEFA Champions League on Wednesday, 26 November 2025.
View our free Atletico Madrid vs Inter Milan predictions below.
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Atletico Madrid vs Inter Milan predictions: Goals expected to flow
Key stats
- Three or more goals were scored in five of Inter Milan's last seven matches.
- Atletico Madrid are currently on a five-game winning streak across all competitions.
- The last two clashes between these sides produced goals at both ends.
Correct score prediction: Atletico Madrid 3-2 Inter Milan
To be fair, Inter Milan have enjoyed some fine form of late, having won four of their last five matches across all competitions.
However, in addition to being on a five-match winning streak, Atletico Madrid have had a near-perfect home record across all competitions this season (W9, D1). They have won their last eight competitive home games, scoring over three goals per game on average.
While we believe that Inter will give everything they have to win this match, we are leaning toward Atletico Madrid for the win.
Pre-game odds and win probability: Inter up against it
- HOME: 5/4 (2.25) – 44.4%
- DRAW: 5/2 (3.50) – 28.6%
- AWAY: 21/10 (3.10) – 32.3%
*Odds from Ladbrokes, subject to change
Inter Milan's four-game winning streak ended with a disappointing 1-0 defeat against AC Milan in the Milan derby last weekend. However, the Nerazzuri have been one of the best teams in the UEFA Champions League this season, with four wins in as many games.
On the other hand, Atletico Madrid have two wins and two losses in four UEFA Champions League matches. Interestingly, they have had the best home record so far, winning two of two games at Riyadh Air Metropolitano, with a +6 goal difference.
Ahead of this encounter, Atletico Madrid are the expected winners at 5/4 (2.25). Teams with these odds generally have a 44.4% probability of winning.
Don’t forget to check out more of our best betting tips and predictions after you’ve dissected our Atletico Madrid vs Inter Milan predictions.
Also, bearing in mind that five of Inter Milan's last seven matches went above the 2.5-goal threshold, over 2.5 total goals has an appealing look at 4/5 (1.80). That one has a 55.6% chance of landing.
Most recent H2Hs: Even contest
There have been four encounters between Atletico Madrid and Inter Milan in the last decade, and both teams have two wins apiece in that stretch.
In fact, the most recent clash between these sides was a friendly last month, in which Atletico Madrid emerged victorious after a penalty shootout.
Club Friendly List 10/10/25
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UEFA Champions League 13/03/24
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UEFA Champions League 20/02/24
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Elite Club Friendlies 11/08/18
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Atletico Madrid preview: Eyeing their sixth consecutive victory
Robin Le Normand has not recovered from a knee injury, making him unavailable for this game, while Marcos Llorente, who picked up a new injury in Sunday's slim win over Getafe, will be assessed to confirm his fitness for Wednesday.
Veteran goalkeeper Jan Oblak suffered a knee injury while on duty for Slovenia on 15 November, a setback which kept him out of action in Atleti’s last league encounter. While the 32-year-old is expected to be back in goal for this crucial UEFA Champions League game, at the time of writing, he remains questionable alongside Giuliano Simeone.
Predicted lineup: Musso (GK), Hancko, Gimenez, Molina, Llorente, Gallagher, Koke, Barrios, Simeone, Griezmann & Alvarez.
Last five matches
- Getafe 0-1 Atletico Madrid
- Atletico Madrid 3-1 Levante
- Atletico Madrid 3-1 USG
- Atletico Madrid 3-0 Sevilla
- Real Betis 0-2 Atletico Madrid
Inter Milan preview: Looking to maintain their perfect record
Cristian Chivu’s side are still battling a few injury headaches to midfielders Henrikh Mkhitaryan, who still has thigh problems, and Matteo Darmian, who is unavailable due to a muscle injury.
After coming off the bench in Inter’s last UEFA Champions League outing against Kairat Almaty, Marcus Thuram is set to partner Lautaro Martinez in attack for this game, with the Frenchman looking to add to his two goals and an assist so far in the league phase.
Predicted lineup: Sommer (GK), Dumfries, Bisseck, Akanji, Bastoni, Dimarco, Barella, Calhanoglu, Zielinski, Thuram & Martinez.
Last five matches
- Inter Milan 0-1 AC Milan
- Inter Milan 2-0 Lazio
- Inter 2-1 Kairat Almaty
- Verona 1-2 Inter
- Inter 3-0 Fiorentina
Player to watch: Julian Alvarez
Julian Alvarez has scored in both of Atletico Madrid's home games in the UEFA Champions League this season. The former Manchester City forward will look to return to scoring ways after drawing blanks in his last two appearances.