Real Madrid vs Arsenal prediction, odds & betting tips – 16/04/2025
Can Arsenal complete the job when they travel to Madrid with a three-goal lead? (Photo by Imago)
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Over 2.5 total goals

Seven of Real Madrid’s last eight Champions League fixtures have featured over 2.5 goals and with Los Blancos certain to chase the game, Wednesday’s clash should deliver more excitement.

Real Madrid need a monumental turnaround to beat Arsenal at the Estadio Santiago Bernabeu in the second leg of the quarter-final of the Champions League on Wednesday, 16 April. Read our Champions League predictions for the clash below.

Real Madrid vs Arsenal prediction: Goals likely under the lights in Madrid

Key Stats

  • Real Madrid have lost only one of their last 18 home games in the Champions League.
  • Vinicius Junior has scored seven times in the Champions League for Real Madrid this season.
  • Real Madrid have been conceding 5.57 shots on target per 90 minutes in the Champions League this season.

Correct score prediction: Real Madrid 2-1 Arsenal

Only Inter (3) have conceded fewer goals than Arsenal (6) in the Champions League this season and the resolute Gunners could do just enough to thwart a Real Madrid comeback in Spain. Los Blancos conceded exactly once in each of their last three home games in the competition, so Arsenal can register.

Pre-game odds and win probability: Real Madrid are odds-on favourites

  • HOME: 4/6 (1.67) – 60%
  • DRAW: 29/10 (3.90) – 25.6%
  • AWAY: 4/1 (5.00) – 20%

*odds from Ladbrokes, subject to change

Real Madrid rebounded from last week’s 3-0 loss to Arsenal with a hard-fought 1-0 win at Alaves and the markets have given Los Blancos 60% chance of winning again on Wednesday. Real have just an 11/2 shot at qualifying for the semi-finals, however.

Arsenal dropped points at home to Brentford (1-1) in the Premier League at the weekend, however, the 4/1 underdogs have made progression to the UCL semis a priority. Check out our football tips page for more of the best Champions League predictions.

Most recent H2Hs: Arsenal in command

Arsenal produced a superb display in their 3-0 win over Real Madrid in last week’s first leg in North London and that was the clubs’ first competitive encounter since 2006.

UEFA Champions League 08/04/25

Arsenal

Arsenal

3
Real Madrid

Real Madrid

0

Elite Club Friendlies 24/07/19

Real Madrid

Real Madrid

2 (3)
Arsenal

Arsenal

2 (2)

Real Madrid preview: Tchouameni should return

Ferland Mendy, Eder Militao and Dani Carvajal are injured and unavailable for Real Madrid while Eduardo Camavinga is suspended having been sent off in the first leg. Kylian Mbappe was sent off for a horror tackle against Alaves at the weekend, though he is free to feature on Wednesday. Aurelien Tchouameni also returns from suspension.

Predicted lineup: Courtois (GK), Vasquez, Asencio, Rudiger, Alaba, Valverde, Bellingham, Tchouameni, Rodrygo, Vinicius, Mbappe

Spain La Liga 11/05/25

L

Barcelona

Barcelona

4

Real Madrid

Real Madrid

3

Spain La Liga 04/05/25

W

Celta Vigo

Celta Vigo

2

Real Madrid

Real Madrid

3

Spain Copa del Rey 26/04/25

L

Barcelona

Barcelona

3

Real Madrid

Real Madrid

2

Spain La Liga 23/04/25

W

Getafe

Getafe

0

Real Madrid

Real Madrid

1

Spain La Liga 20/04/25

W

Athletic Bilbao

Athletic Bilbao

0

Real Madrid

Real Madrid

1

Arsenal preview: No Partey for visitors

Arsenal will be without Riccardo Calafiori, Gabriel Magalhaes, Kai Havertz and Gabriel Jesus are sidelined through injury, while Thomas Partey is being left at home. Jorginho could be drafted into Mikel Arteta's midfield to replace Partey.

Predicted lineup: Raya (GK), Timber, Saliba, Kiwior, Lewis-Skelly, Jorginho, Odegaard, Rice, Saka, Martinelli, Merino

England Premier League 11/05/25

D

Liverpool

Liverpool

2

Arsenal

Arsenal

2

UEFA Champions League 07/05/25

L

PSG

PSG

2

Arsenal

Arsenal

1

England Premier League 03/05/25

L

Bournemouth

Bournemouth

2

Arsenal

Arsenal

1

UEFA Champions League 29/04/25

L

PSG

PSG

1

Arsenal

Arsenal

0

England Premier League 23/04/25

D

Crystal Palace

Crystal Palace

2

Arsenal

Arsenal

2

Player to watch – Declan Rice

Declan Rice was undoubtedly the star of the show in Arsenal’s sensational 3-0 quarter-final first-leg win over Real Madrid at The Emirates Stadium, hitting two “Roy of the Rovers” style free kicks from distance past Thibaut Courtois.

Real Madrid vs Arsenal prediction
Two-goal Declan Rice was the star of Arsenal's 3-0 win over Real Madrid in the first leg. (Photo by Imago)

Could Rice be the protagonist again?

Rampaging midfielder Rice will probably have more of a defensive remit in Wednesday’s second leg, though the England regular can still have a big say in the outcome of the contest, albeit from a less attacking perspective.


Simon Winter is a professional football tipster and sports journalist with over ten years in the industry. Best known for his time with Racing Post, Simon has also had work published by Freesupertips, Bloomberg Sports, bet365, Paddy Power, Colossus Bets, These Football Times and more. Simon covers the Bundesliga and Serie A for Football Whispers.