* Betting odds were correct at the time of publication but are subject to change
Napoli and Ajax go head-to-head for three points in Champions League Group A on Wednesday, October 12th. Napoli can book their place in the next round with a victory over the Dutch side. Read our free predictions and find the latest odds for the fixture below in our detailed match preview.
Napoli vs Ajax – Free Betting Tips & Predictions
Napoli hammered Ajax 6-1 in Amsterdam last week. Can the Italians beat the Dutch giants again on Wednesday? Read our top predictions for this week’s fixture below.
Contents
Napoli to Win
Napoli produced one of the Champions League performances of the season last week when they put six goals past Ajax in Amsterdam and that was the Italians’ fourth victory in as many games in Group A. Luciano Spalletti’s side have won eight games on the bounce in all competitions overall and they are playing with a swagger that Ajax should find tough to combat in Naples. The prices for a home win are generous here and we recommend backing the hosts to book their place in the knock out rounds with another three points on Wednesday.
Over 2.5 Goals
Luciano Spalletti has Napoli playing a superb brand of attacking football and the Partenopei look like scoring buckets of goals whenever or whoever they play. Incredibly, they’ve rattled the net 13 times in just three Champions League group matches so far, while seven of their last eight contest have produced over 2.5 goals. More action is on the cards on Wednesday in Naples where another stake on over 2.5 goals could return dividends.
Top Betting Odds and Stats for Napoli vs Ajax
View our list of the top stats for Wednesday’s game below alongside a tool to help you choose the most lucrative odds.
Head to Head
04/10/22
UEFA Champions League UCL
Ajax
Napoli
1
6
Last Five - Ajax
11/05/25
Netherlands Eredivisie Netherlands
NEC
Ajax
3
0
L
27/04/25
Netherlands Eredivisie Netherlands
Sparta Rotterdam
Ajax
1
1
D
20/04/25
Netherlands Eredivisie Netherlands
FC Utrecht
Ajax
4
0
L
13/04/25
Netherlands Eredivisie Netherlands
Willem II
Ajax
1
2
W
06/04/25
Netherlands Eredivisie Netherlands
NAC
Ajax
1
3
W
Napoli vs Ajax Team News & Injuries
Read all of the latest injury updates and team news for Wednesday’s Champions League contest between Napoli and Ajax below.
Napoli Predicted Lineup
Victor Osimhen is still nursing a hamstring injury and he is unlikely to be risked this week with more important fixtures on the horizon. Napoli need just one more win to guarantee their place in the next round of the Champions League and they are favourites to get the victory they need on Wednesday.
Predicted Lineup for Napoli: Meret – Di Lorenzo, Rrahmani, Min-Jae, Olivera – Anguissa, Lobotka, Zielinski – Lozano, Kvaratskhelia, Raspadori
Ajax Predicted Lineup
Ahmetcan Kaplan and Jorge Sanchez are both listed as absent for Ajax, though neither defender is likely to have started in Naples, even if they were fit. Dusan Tadic is suspended having been sent off last week. Ajax snapped a four-match winless run with a 4-2 triumph at Volendam on Saturday, though their performance was far from convincing again.
Predicted Lineup for Ajax: Pasveer – Rensch, Timber, Bassey, Blind – Alvarez, Taylor – Klassen, Berghuis, Bergwijn – Kudus
Napoli vs Ajax Coverage and Frequently Asked Questions

Where can I find the best odds for this game?
Here at Football Whispers, we’ve compiled some of the best odds from several bookmakers for Napoli’s clash with Ajax.
What time does this fixture kick off?
The game is scheduled to start at 17:45 BST.
Which team is favourite to win this week?
The bookmakers have priced Napoli as favourites to beat Ajax on Wednesday.