Ajax have only lost once in the Europa League this season and currently sit comfortably in the qualifying spots but this week they face a Lazio side that are yet to taste defeat in this competition.
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Ajax vs Lazio prediction: Lazio to avoid first loss?
Key Stats
- Ajax have lost two and drawn two of their last six matches across all competitions.
- Lazio head into Thursday's match on the back of four wins, one draw and just one defeat from their last six outings.
- Both teams have scored in four of Ajax's last six matches.
Correct score prediction: Ajax 1-2 Lazio
Lazio have won four of their opening five matches in this season's Europa League and we can see the Italians coming away with a narrow victory again on matchday six. Ajax have lost two of their last four fixtures, including their last outing in this competition against Real Sociedad.
Pre-game odds and win probability: Ajax the bookmaker's pick
- HOME: 13/10 (2.30) – 43.5%
- DRAW: 27/10 (3.70) – 27%
- AWAY: 11/5 (3.20) – 31.3%
*odds from Ladbrokes, subject to change
Ajax are the expected winner of this game with a probability of 43.5% but we can see Lazio getting something out of this game.
You can find all our predictions for today's games on our football betting tips page.
Most recent H2Hs: Never met before
Ajax come up against Lazio for the first time in the pair's history which is a big surprise considering how much European football both teams have competed in over the years.
Ajax preview: Guilty of being hit and miss
Dutch giants Ajax made the trip to AZ Alkmaar on Sunday where the first half at the AFAS Stadion ended goalless.
Former Tottenham striker Troy Parrott fired the home side in front in the 65th minute and Mayckel Lahdo made it 2-0 11 minutes later. Mika Godts did manage to pull a goal back for Ajax late on but the game ended in defeat for Francesco Farioli's men.
Midfielders Benjamin Tahirovic, Julian Rijkhoff and Sivert Mannsverk are all doubts for Thursday's clash, while defender Gaston Avila could also miss out through injury.
Predicted lineup: Pasveer (GK), Sutalo, Baas, Gaaei, Hato, Klaassen, van den Boomen, Taylor, Berghuis, Akpom & Weghorst
Netherlands Eredivisie 11/05/25
L
NEC
3
Ajax
0
Netherlands Eredivisie 27/04/25
D
Sparta Rotterdam
1
Ajax
1
Netherlands Eredivisie 20/04/25
L
FC Utrecht
4
Ajax
0
Netherlands Eredivisie 13/04/25
W
Willem II
1
Ajax
2
Netherlands Eredivisie 06/04/25
W
NAC
1
Ajax
3
Lazio preview: Going strong in the Europa League
Lazio went up against Napoli on Sunday night in Serie A having just beaten the very same opponent in the Coppa Italia in midweek.
This time the game proved much more tight and tense with a solitary second-half effort from Gustav Isaksen winning the game for Lazio.
Midfielder Matias Vecino looks set to miss the trip to Amsterdam due to injury.
Predicted lineup: Provedel (GK), Romagnoli, Marusic, Tavares, Gila, Zaccagni, Guendouzi, Dele-Bashiru, Isaksen, Castellanos & Dia
Italy Serie A 10/05/25
D
Juventus
1
Lazio
1
Italy Serie A 04/05/25
W
Empoli
0
Lazio
1
Italy Serie A 28/04/25
D
Parma
2
Lazio
2
Italy Serie A 23/04/25
W
Genoa
0
Lazio
2
UEFA Europa League 17/04/25
W
Bodo/Glimt
1
Lazio
3
Player to watch: Pedro
Lazio's 37-year-old forward Pedro has only started three league games for the club this season but the former Barcelona man has been in the starting lineup for each of Lazio's five Europa League games.

The skillful forward has scored three goals in the Europa League this season, as well as chipping in with one assist, and he is our player to watch on Thursday night.
Lazio's veteran forward has shone in the Europa League
We can see Pedro causing the Ajax defence plenty of issues this week and wouldn't bet against the veteran forward adding to his European goal tally in this game.