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AC Milan - Sampdoria
Italy Serie A - Giuseppe Meazza
* Betting odds were correct at the time of publication but are subject to change
AC Milan and Sampdoria lock horns at the Stadio Giuseppe Meazza in Italy’s Serie A on Saturday, May 20th. Can Milan pick themselves up after their Champions League disappointment to beat Sampdoria? Read our Serie A predictions along with the latest odds for the fixture below in our detailed match preview.
Today's Predictions for AC Milan vs Sampdoria
AC Milan are favourites to beat already relegated Sampdoria when the teams clash in Serie A on Saturday. Read our top AC Milan vs Sampdoria predictions for this weekend’s fixture below. If you’re searching for more of the best football tips for today, we recommend checking out our dedicated page by clicking the link.
Contents
AC Milan to Win to Nil
AC Milan will be licking their wounds following their Champions League semi-final exit at the hands of rivals Inter in midweek, however, if they want to make the cut for next season’s tournament, they need to get their top four charge in Serie A back on track, starting with Saturday’s clash with Sampdoria. The visitor’s relegation has already been confirmed and having lost three of their last four matches to nil, La Samp could suffer the same fate when they take on a Milan outfit with a point to prove.
AC Milan -1.0 Goal Handicap
Milan will feel like they owe their supporters a performance following a run of three straight defeats and the Rossoneri could put their foot down on the acceleration to take out their frustrations again Sampdoria on Saturday. La Samp allowed their hosts to cover a one goal handicap in four of their last five games on the road, and the division’s bottom club could be swatted aside with equal comfort by Milan.
Top Betting Odds and Stats for AC Milan vs Sampdoria
Check out our list of key stats for Saturday’s match below alongside a tool to help you choose the best AC Milan vs Sampdoria odds.
Head to Head
10/09/22
Italy Serie A Serie A
Sampdoria
AC Milan
1
2
13/02/22
Italy Serie A Serie A
AC Milan
Sampdoria
1
0
23/08/21
Italy Serie A Serie A
Sampdoria
AC Milan
0
1
03/04/21
Italy Serie A Serie A
AC Milan
Sampdoria
1
1
06/12/20
Italy Serie A Serie A
Sampdoria
AC Milan
1
2
Last Five - AC Milan
09/05/25
Italy Serie A Serie A
Bologna
AC Milan
1
3
W
05/05/25
Italy Serie A Serie A
Genoa
AC Milan
1
2
W
27/04/25
Italy Serie A Serie A
Venezia
AC Milan
0
2
W
23/04/25
Coppa Italia Coppa
Inter Milan
AC Milan
0
3
W
20/04/25
Italy Serie A Serie A
Atalanta
AC Milan
1
0
L
Last Five - Sampdoria
13/05/25
Italy Serie B Italy
Juve Stabia
Sampdoria
0
0
D
09/05/25
Italy Serie B Italy
Salernitana
Sampdoria
0
1
W
04/05/25
Italy Serie B Italy
Catanzaro
Sampdoria
2
2
D
01/05/25
Italy Serie B Italy
Cremonese
Sampdoria
0
0
D
25/04/25
Italy Serie B Italy
Carrarese
Sampdoria
1
0
L
Let's take a closer look at the latest markets, odds and probability figures ahead of Saturday’s clash featuring AC Milan vs Sampdoria below.
AC Milan odds: 1/5 (1.20) – 83.3%
Draw odds: 27/5 (6.40) – 15.6%
Sampdoria odds: 15/1 (16.00) – 6.3%
AC Milan are the bookies’ clear expected winners on Saturday with a probability of a home victory set at 83.3%. Elsewhere, over 2.5 goals is favoured ahead of unders in the market at 4/7 (1.57). That outcome comes equipped with an implied probability of 63.6%. favourites Milan could be worth checking out at 3/5 (1.60) in the half time result market too.
AC Milan vs Sampdoria News & Injuries
Read all of the latest injury updates, AC Milan vs Sampdoria lineups and team news for Saturday’s fixture below.
AC Milan
Ismaël Bennacer faces an extended spell in the sidelines with a knee problem, though Milan's treatment room is virtually empty beyond that. Rafael Leao returned from injury in midweek in Milan's 1-0 loss to Inter in the Champions League semi-finals and the Portuguese winger could start again on Saturday.
Predicted Lineup for AC Milan: Maignan – Calabria, Kjaer, Tomori, Hernandez – Krunic, Tonali – Diaz, Saelemaekers, Rebic, Origi
Sampdoria
Keeper Emil Aduero, defender Andrea Conti and attacker Ignacio Pussetto are all considered doubts and might not feature for Sampdoria while attacker Medhi Leris is a confirmed absentee with a muscle issue. La Samp drew 1-1 at home to Empoli last time out, though they are still rooted to the foot of the table.
Predicted Lineup for Sampdoria: Ravaglia – Gunter, Nuytinck, Amione – Zanoli, Winks, Rincon, Augello – Duricic, Gabbiadini, Quagliarella
Player to Watch – Divock Origi
Divock Origi started in a rotated Milan team at Spezia last weekend and the Belgian striker could be given another shot from the first whistle against Sampdoria on Sunday. Origi hasn’t scored a goal for Milan since January and the 28-year-old will be itching to make an impact this weekend.
Starting Lineups
Official lineups are usually released approximately one hour before kick-off.
AC Milan
Sampdoria
AC Milan vs Sampdoria Coverage and Frequently Asked Questions

Who are the current Serie A champions?
Napoli have just been crowned as Serie A champions for the first time since 1990. Check out our AC Milan vs Sampdoria prediction near the top of our preview.
What time does this fixture kick off?
The game is scheduled to start at 19:45 BST.
Which bookmaker has the best odds for this game?
We recommend checking out the odds at Stake and Ladbrokes for Saturday’s Serie A contest.