Will Laguneros be able to replicate their amazing display against Toluca last week or will Atletico San Luis emerge victorious at home on the 29th of September? The answer to this question is located in the following Atletico San Luis vs Santos Laguna betting tips. Don’t hesitate to check out what Football Whispers’ experts had to say.
Top Liga MX predictions can be easily accessed by visiting FW’s website.
Contents
- 1 Atletico San Luis vs Santos Laguna prediction: Laguneros’ run to continue
- 2 Last five H2Hs: Atletico eager to rack another win
- 3 Atletico San Luis team news and form: Inconsistency ruins Atletico’s plans
- 4 Santos Laguna team news and form: Laguneros’ manager with injury issues on his mind
- 5 Player to watch: Frank Boli
Atletico San Luis vs Santos Laguna prediction: Laguneros’ run to continue
Key Stats
- Laguneros won their last official Liga MX game.
- We saw under 2.5 goals in Santos Laguna’s last domestic league game.
- The visitors have a staggering head-to-head advantage, consisting of six wins, two draws, and only two losses against Atletico San Luis.
Correct score prediction: Atletico San Luis 0-2 Santos Laguna
The visitors’ last official game ended 2-0 in their favor. This is yet another plus in favor of our top Atletico San Luis vs Santos Laguna predictions, as Laguneros’ last victory against this opponent had 2-0 on the scoreboard as well.
Pre-game odds and win probability: No chance for Laguneros despite recent success
- HOME: -175 – 62.2%
- DRAW: +325 – 22.8%
- AWAY: +430 – 15.0%
*These Atletico San Luis vs Santos Laguna odds are subject to change
BTTS – No is currently being priced by the bookmakers at -119. This means we have a 54.34% chance of seeing BTTS – No at Estadio Alfonso Lastras this week.
In the meantime, the home team’s players are considered by the experts as the expected winners, as they have a 62.2% win probability.
Last five H2Hs: Atletico eager to rack another win
If you check the Atletico San Luis vs Santos Laguna statistics below, you’ll find out why we favor the visitors.
Mexico Liga MX 29/04/24
Santos Laguna
Atletico San Luis
Mexico Liga MX 11/11/23
Atletico San Luis
Santos Laguna
Mexico Clausura 18/02/23
Atletico San Luis
Santos Laguna
Mexico Apertura 29/08/22
Santos Laguna
Atletico San Luis
Mexico Clausura 01/05/22
Atletico San Luis
Santos Laguna
Atletico San Luis team news and form: Inconsistency ruins Atletico’s plans
Coach Domenec Torrent’s players are taking turns losing and winning. In the last five Liga MX matches, we saw them lose three times and win only two games. If they want to disprove our Atletico San Luis vs Santos Laguna predictions, they’d have to show us something more.
Predicted lineup: Rodriguez (GK), Castro, Dominguez, Chavez, Sanabria, Guemez, Dourado, Reyna, Salles-Lamonge, Lemos & Boli
Mexico Liga MX 21/04/25
W
Pachuca
1
Atletico San Luis
2
Mexico Liga MX 17/04/25
L
Toluca
1
Atletico San Luis
0
Mexico Liga MX 11/04/25
L
Tijuana
2
Atletico San Luis
1
Mexico Liga MX 06/04/25
W
Mazatlan FC
1
Atletico San Luis
2
Mexico Liga MX 30/03/25
W
Santos Laguna
2
Atletico San Luis
3
Santos Laguna team news and form: Laguneros’ manager with injury issues on his mind
Jordan Carrillo picked up a brutal collateral ligament injury a while ago and will once again miss a Santos Laguna game. He is expected to make a return at the end of next month, but we are sure that the visitors have enough quality players on the wing to replace him.
Predicted lineup: Lopez (GK), Nunez, Santamaria, Mata, Vargas, Naveda, Mariscal, Sorbo, Fagundez, Villaba & Lozano
America Friendlies 29/06/25
L
Cruz Azul
2
Santos Laguna
0
Club Friendly List 28/06/25
D
Chivas Guadalajara
2
Santos Laguna
2
Mexico Liga MX 20/04/25
L
Tijuana
4
Santos Laguna
0
Mexico Liga MX 17/04/25
L
Unam Pumas
2
Santos Laguna
0
Mexico Liga MX 13/04/25
L
Queretaro
2
Santos Laguna
1
Player to watch: Frank Boli
Boli is not only Atletico San Luis’ top goalscorer this season, but he is also one of the most frequent scorers in Liga MX in general. With four goals since the start of the season, his confidence is undoubtedly flying off the charts. He will surely try to ruin our Atletico San Luis vs Santos Laguna predictions this week.

Second player to watch: Carlos Acevedo
Acevedo was Laguneros’ big hero in the match against Toluca last week. The visitors at Estadio Corona made a massive 18 shots at target, but Acevedo’s cat-like reflexes helped the team achieve a clean sheet.