Santos Laguna seem like dead men walking ahead of the kick-off versus almighty FC Cincinnati on the 10th of August. Can Laguneros get anything out of the math at TQL Stadium or will coach Pat Noonan give the Mexican visitor something to think about? You’ll know the answer if you read our Cincinnati vs Santos Laguna betting tips.
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Cincinnati vs Santos Laguna prediction: Laguneros can’t win this
Key Stats
- Santos Laguna couldn’t win either one of their Leagues Cup games in regular time.
- Cincinnati are performing quite well in MLS, with 15 wins, three draws, and seven losses.
- Acosta is the leading goalscorer for his team, with 11 goals this season.
Correct score prediction: Cincinnati 3-0 Santos Laguna
Laguneros couldn’t score in their last Leagues Cup game against Atlanta United. They had to rely on the penalty roulette to advance to the next stage of the competition. They lost 3-0 to DC United as well. Surely, our Cincinnati vs Santos Laguna predictions have a solid success chance.
Pre-game odds and win probability: FC Cincinnati with a routine win
- HOME: -166 – 61.1%
- DRAW: +320 – 21.9%
- AWAY: +410 – 17.0%
*These Cincinnati vs Santos Laguna odds are subject to change
Luciano Acosta to score first is our favorite pick for the Cincinnati vs Santos Laguna head-to-head. The odds are valued at +220, meaning the 2023 MLS’ Player of the Season stands a massive 31.25% chance of scoring the first goal at TQM Stadium. Cincinnati are the expected winners as well. They have a mind-blowing 61.1% chance of besting Laguneros.
Last five H2Hs: A day for history!
Sadly, we have no Cincinnati vs Santos Laguna statistics to show you, as this game is going to be the first one between the two teams.
Cincinnati team news and form: Cincinnati seek glory
Cincinnati demolished in-form New York City in their last official game. The result was 4-2 but could’ve easily been more humiliating for New York City, as coach Noonan’s players had a whopping 19 shots at target.
Predicted lineup: Walters (GK), Powell, Keller, Murphy, Orellano, Nwobodo, Pinto, Halsey, Valenzuela, Acosta & Baird
USA MLS 12/04/25
W

DC United
0

FC Cincinnati
1
USA MLS 05/04/25
W

New England Revolution
0

FC Cincinnati
1
USA MLS 30/03/25
W

Nashville SC
1

FC Cincinnati
2
USA MLS 22/03/25
D

Atlanta United
2

FC Cincinnati
2
USA MLS 15/03/25
L

Charlotte FC
2

FC Cincinnati
0
Santos Laguna team news and form: Toothless attack root of all troubles
Without Harold Preciado among the starters, Santos Laguna just can’t score. The Colombian goalscorer is suspended and won’t partake in the match at TQL Stadium either. This is a huge plus in favor of our Cincinnati vs Santos Laguna prediction, as he was the top finisher for his team last season.
Predicted lineup: Lopez (GK), Amione, Santamaria, Nunez, Medina, Mariscal, Naveda, Sordo, Fagundez, Carrillo & Lozano
Mexico Liga MX 13/04/25
L

Queretaro
2

Santos Laguna
1
Mexico Liga MX 07/04/25
L

Toluca
2

Santos Laguna
1
Mexico Liga MX 30/03/25
L

Atletico San Luis
3

Santos Laguna
2
Mexico Liga MX 15/03/25
L

Tigres UANL
3

Santos Laguna
0
Mexico Liga MX 09/03/25
W

Leon
1

Santos Laguna
2
Player to watch: Luciano Acosta
Sadly, we didn’t get to see Acosta in action for FC Cincinnati in the match versus New York City last week. However, we are convinced the Argentine maestro will play versus Laguneros. Not only did he score 11 MLS goals, but he also helped his teammates with 15 assists.

Second player to watch: Carlos Acevedo
Acevedo is the key Santos Laguna shot-stopper. Seeing as the team is performing quite poorly this season, Acevedo sees a lot of action. We are sure that he will do his best to ruin our Cincinnati vs Santos Laguna predictions as well.