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There was absolutely nowhere for Dejan Lovren to hide. Liverpool were 2-0 down inside 12 minutes against Tottenham at Wembley and the big Croatian was at fault for both of them.

The visiting manager Jurgen Klopp knew it was time to be ruthless and he hooked Lovren after just 31 minutes, replacing him with Alex Oxlade-Chamberlain and switching to a 3-5-2 formation which appeared to shore up the visitors for a few minutes at least.

Klopp confirmed afterwards that there was no injury to the central defender, only that he needed to change the system. He also pointed out that the change did not make much of a difference as Liverpool went on to concede another two and lose 4-1.

Here Football Whispers looks back on some other examples of manager brutality by way of substitutions to find out if it ever really works.

1) Emmanuel Eboué v Wigan Athletic, December 6, 2008

Depending who you ask, Ivorian Eboué was regarded as either a figure of fun or a cult hero during his seven years at Arsenal, but things got really toxic for him in December 2008 during a home match against Wigan.

Eboué had been brought on in the 32nd minute to replace the injured Samir Nasri with the Gunners leading 1-0. However the frustration inside the stadium grew as Arsenal failed to build on an early advantage despite almost complete control.

The defender bore the brunt of the fans' anguish and he was jeered by sections of the support. Sensing the despair, Arsène Wenger subbed him back off with just a minute left against a back drop of booing.

It looked like there would be no way back for Eboue but he actually went on to play 29 more times that season and did not leave the club for another two years.

2) Cláudio Caçapa v Portsmouth, November 3, 2007

Hearing the name Caçapa still makes some Newcastle fans shudder to this day, especially those present at St James's Park on a chilly November afternoon in 2007.

The ageing Brazilian centre-back was at fault for two of Pompey's early goals as they raced into a 3-0 lead within 11 minutes. The home side managed to haul themselves back into the game in the 16th minute with a goal and Sam Allardyce wasted no time in hauling him off just seconds later with the score at 3-1.

However, despite the switch for David Rozehnal, Caçapa's departure did not inspire a great come back as Newcastle went on to lose 4-1. He did not reappear in the first team for another five weeks but went on to make a further 12 appearances that season, during which the Magpies conceded a total of 27 goals.

3) Wes Foderingham v Preston, September 2, 2012

Paulo Di Canio's contribution to the list came away from the Premier League spotlight but was no less harsh – and it involved his goalkeeper. Swindon had made an impressive start to their League One campaign, winning two and drawing one of their opening three games, and keeper Wes Foderingham was yet to concede a league goal.

However that changed as they visited Preston North End in September 2012 as the home side scored twice within 15 minutes. Di Canio felt that Foderingham was at fault for the first goal and hauled him off after just 21 minutes, much to the keeper's horror.

It made little difference as, just like Liverpool did on Sunday and Newcastle did in 2007, Swindon eventually lost 4-1.

But the story does not end there – apparently Di Canio was so disgusted by the performance that he did not let Foderingham ride the team bus back to Swindon and he had to get a train back from Preston.

4) Nemanja Matic v Southampton, October 3, 2015

Chelsea were drawing 1-1 at Stamford Bridge when Jose Mourinho decided to introduce Matic at half time. However the Serbian midfielder would last just 28 minutes as Chelsea fell 3-1 behind. As a result, Mourinho decided to withdraw Matic to widespread boos as the champions slumped to their fourth defeat of the campaign.

Unsurprisingly, Matic decided not to shake his manager's hand as he trudged off to be replaced by Loic Remy. It was about as brutal as it gets from a manager but he insisted his decision to sub the sub was not a humiliation. “I know they are good players but some of them are in a difficult moment – Matic is one of them,” Mourinho said afterwards. “He is not playing well. He is not sharp defensively. He is making mistakes with the ball and not making the best decisions. It was not humiliating.”

5) Robert Pirès v Barcelona, May 17, 2006

This one might just be the most brutal substitution on the list – but for a very different reason. Pirès had not been playing badly in the Champions League final against Barcelona at the Stade de France in Paris, in fact he had made a promising start to the clash.

However, when goalkeeper Jens Lehmann was sent off in the 18th minute, Arsene Wenger had to act and he hooked poor old Pirès for Manuel Almunia.

Pires later said he thought it was a practical joke when his number was held up by the fourth official after just 20 minutes of the biggest game in his club career.

The 10 men of Arsenal took a shock lead in the 37th minute through Sol Campbell but lost 2-1 after conceding twice in the final 14 minutes. Pirès never played for Arsenal again. “I could see in the final against Barcelona, Wenger had lost his confidence in me,” Pirès said. “The fact that I was only allowed to play 18 minutes in that final remains painful. I'll never agree with him that he made the right decision.”