Seleção talisman Cristiano Ronaldo has four goals in three games and will be desperate to not only build on that tally in the battle for the Golden Boot, but earn his moment of redemption after limping out of Portugal's Euro 2016 final triumph with injury.
Uruguay, meanwhile, made it through Group A with maximum points but rarely looked their fluid best despite an enviable forward line of Edinson Cavani and Luis Suárez. They will hope to click now knockout football is here.
Our unique algorithm has predicted the Portugal side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, and the statistical likelihood of a player being selected. The widget can also show you players' recent form and stats.