In recent years the Saints have sold off a number of stars to the Reds, the latest being Virgil van Dijk who moved to Anfield for £75million in January, a world record fee for a defender.
This weekend the Dutchman will return to St Mary's as the Reds take on Southampton in the Premier League. Van Dijk is expected to feature in the heart of Jürgen Klopp's defence, but he's unlikely to be the only ex-Saints star in the starting XI.
But how well do you know your history? In total 12 different players have represented both Liverpool and Southampton in the Premier League, but can you remember them all?
We've given you five minutes to recount the players, let us know how you get on by tweeting us @FB_Whispers. Oh, and if you're struggling to get the quiz to work, make sure your AdBlocker is disabled. Good luck!