It's a fixture which almost always throws up fiercely-contested, goal-laden, memorable encounters.
Jürgen Klopp's men, with just one win in six, host second-placed Manchester United who will be looking to extend their unbeaten run. José Mourinho's side have won six and drawn just one so far. The Portuguese won't want to give that record up without a fight.
Unsurprisingly, this feisty local derby has been the scene of numerous red cards. Sixteen, in fact, making it the Premier League‘s second dirtiest fixture behind the Merseyside derby between Liverpool and Everton.