Tottenham's troubles at Wembley Stadium have been well publicised but Mauricio Pochettino's side upset the form guide last week with a 3-1 win over Borussia Dortmund in the Champions League.
However, they were frustrated in their next home fixture as Swansea City held them to a goalless draw under the arch. They are yet to win at the national stadium in the Premier League this term.
However, on Saturday, Spurs get the chance to return to winning ways as they make the short hop to Stratford to take on Slaven Bilić's West Ham side.
The Hammers, who were beaten in their first three Premier League fixtures, have switched to a 3-4-3 system and picked up four points from their last two games following the tweak.
Pochettino has found joy setting up in a back three and now the only question marks are over who will clinch the wing-back spots on Saturday.
Serge Aurier was impressive on his full debut against Dortmund but Kieran Trippier has hardly put a foot wrong and Pochettino has stuck with the former Burnley defender in the league.
On the left, Manchester United transfer target Danny Rose (knee) is still sidelined by injury. Ben Davies has filled in admirably and been one of Tottenham's most potent attacking threats in the early weeks of the season.
But he was suddenly dropped for Sunday's stalemate against the Swans with Heung-min Son brought into the side. The South Korean has never looked comfortable at wing-back and should make way this weekend.
Moussa Sissoko, who flopped horribly following his £30million switch from Newcastle United last summer, has been given a second chance this season and will battle with Mousa Dembélé and Eric Dier for one of the central midfield berths.
Also missing out are midfield enforcer Victor Wanyama (knee) and winger Erik Lamela (hip).
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