Spurs have won four of their last five top flight games and are now outside the top four by three points.
Mauricio Pochettino will be in familiar territory when he takes his men to St Mary's but will take no pity on his former employers who are struggling under Mauricio Pellegrino this season.
Our unique algorithm has predicted the Tottenham side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.