The Red Devils are heavy favourites to win the game, despite the likelihood of José Mourinho rotating his side ahead of the busy festive period of games.
Zlatan Ibrahimović could start the contest while there are also likely to be changes in midfield and defence.
Our unique algorithm has predicted the Manchester United side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.