They will be favourites for the win here, though, meaning Pellegrini's new-look Irons have their work cut out for them if they are to move past the disappointment of throwing away a 1-0 lead in the home defeat to Bournemouth.
Pellegrini is still trying to establish his first-choice starting XI. For the Bournemouth game, the Chilean made three changes from the opening-day defeat to Liverpool, with Pablo Zabaleta, Robert Snodgrass and Javier Hernández replacing Declan Rice, Ryan Fredericks and Michail Antonio.
After the manner in which West Ham failed to see the game out against the Cherries, Pellegrini may make further changes, with transfer deadline day signings Lucas Pérez (formerly of Arsenal) and Carlos Sánchez pushing for starts.
Andriy Yarmolenko, the £17.5million summer capture from Borussia Dortmund, may also make his first start.
Our unique algorithm has predicted the West Ham side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, and the statistical likelihood of a player being selected. The widget can also show you players' recent form and stats.