Mauricio Pochettino's side reached the semi-finals last season only to lose 4-2 to Premier League winners Chelsea under the famous Wembley arch.
Knocked out of the Champions League by Juventus last week, the FA Cup represents Tottenham's last chance of silverware this season and it's a game Pochettino's men will be favourites to win.
Danny Rose (cramp), Dele Alli (groin) and Ben Davies (tiredness) are all doubts for Spurs.
Our unique algorithm has predicted the Tottenham side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, the statistical likelihood of a player being selected, the competition the match is in, players’ previous performances and the opponent’s style.
And you can also give it a go yourself. Just click ‘create your own’ on the line-up at the top of the page and pick your ideal XI for the game.You can also see each player’s stats once you’ve selected them.
When you’re happy with your team, press confirm and you’ll be able to share it with your friends via social media.