“This is quite incredible, Gareth Bale has scored a hat-trick at the San Siro.”
When the men from North London first tasted Champions League football in the 2010/11 season, they faced then European champions Inter. The Lilywhites were quickly brought back down to earth with the Italians blitzing Harry Redknapp's men, giving them a 4-0 half time lead.
A young Welsh winger then went onto score a hat-trick in the second half and despite Spurs losing, they showed some fight and went on to seek revenge in the return game at White Hart Lane, winning 3-1.
Unfortunately that young man didn't go on to do much with his career – if you ignore the four Champions League winner's medals and several other major honours, of course.
Some say those two games transformed Gareth Bale into the player he now is. He gave one of the best right backs in the world at that point, Maicon, a torrid time.
Spurs also went back to the San Siro in their last-16 tie that season to face, City rivals, AC Milan, beating them over two legs.
As for 2018, Mauricio Pochettino will hope his side can put in a more spirited performance than in their recent 2-1 home defeat to Liverpool, which was one of the worst performances since the Argentine took the reigns at Tottenham.
They will, however, take confidence from coming through their Champions League group of death last season, which contained Real Madrid and Borussia Dortmund.
Spurs didn't lose a single game in the group stage last season yet with Barcelona coming to London in two weeks time, they will want to make a winning start and take three points back to London.
It may well be time, for another, ‘Glory Glory night' for Tottenham Hotspur.
But who will be the men to take to the field? Our unique algorithm has predicted the Tottenham side it believes will start the game.
Football Whispers uses data to predict teams’ starting XIs, taking into account injuries, suspensions, and the statistical likelihood of a player being selected. The widget can also show you players' recent form and stats.
So pick your team, share with with your friends and family on social media and see how they compare.